{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:54:00Z","timestamp":1787061240815,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T00:00:00Z","timestamp":1610409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate partial HPV16\/18 genotyping as a possible biomarker to select women attending HPV\u2010based cervical cancer screening at higher risk to be referred to colposcopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Population\u2010based cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Organised cervical cancer screening programmes (Italy).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>Women with high\u2010risk HPV infection (period: 2015\u20132019).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We analysed the association between partial HPV16\/18 genotyping, cytology triage and histologically confirmed diagnosis of high\u2010grade cervical intraepithelial neoplasia (CIN3\n                      <jats:sup>+<\/jats:sup>\n                      ) lesions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measures<\/jats:title>\n                    <jats:p>\n                      Detection rate (DR) and positive predictive value (PPV) for histologically confirmed CIN3\n                      <jats:sup>+<\/jats:sup>\n                      (any episode in the 2 years after baseline); sensitivity for CIN3\n                      <jats:sup>+<\/jats:sup>\n                      and number of colposcopies needed for lesion detection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study included 145\u00a0437 women screened with HPV testing by the clinically validated COBAS 4800 HPV assay (Roche). Overall, 9601 (6.6%) women were HPV\n                      <jats:sup>+<\/jats:sup>\n                      at baseline; HPV16 and HPV18 were present in 1865 and 594 samples, respectively. The cumulative (baseline plus 1\u2010year repeat) cytology positivity was 42.8% and high\u2010grade cytology was significantly higher (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001) among women with HPV16 infection at baseline (15.2%). The cumulative CIN3\n                      <jats:sup>+<\/jats:sup>\n                      DR for women with HPV16, HPV18 and other HPV\u2010type infections was 9.8%, 3.4% and 1.8%, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Partial HPV16 genotyping may play a role in triage, whereas HPV18 seems to behave much more similarly to the other HPV types and does not provide additional stratification. HPV16 genotyping combined with high\u2010grade cytology can be envisaged as a triage biomarker in cervical screening to maximise CIN3\n                      <jats:sup>+<\/jats:sup>\n                      detection while minimising colposcopy at baseline or 1\u2010year repeat.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Tweetable abstract<\/jats:title>\n                    <jats:p>\n                      HPV16 genotyping combined with high\u2010grade cytology can be used as triage biomarker for CIN3\n                      <jats:sup>+<\/jats:sup>\n                      in HPV\u2010positive women.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1471-0528.16631","type":"journal-article","created":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T14:38:48Z","timestamp":1608215928000},"page":"1353-1362","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Clinical relevance of partial HPV16\/18 genotyping in stratifying HPV\u2010positive women attending routine cervical cancer screening: a population\u2010based cohort study"],"prefix":"10.1111","volume":"128","author":[{"given":"S","family":"Gori","sequence":"first","affiliation":[{"name":"Immunology and Diagnostic Molecular Oncology Unit Veneto Institute of Oncology IOV\u2010IRCCS Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Battagello","sequence":"additional","affiliation":[{"name":"Veneto Tumour Registry Azienda Zero Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Gustinucci","sequence":"additional","affiliation":[{"name":"Laboratorio Unico di Screening USL Umbria 1 Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Campari","sequence":"additional","affiliation":[{"name":"Cancer Screening Unit Azienda Unit\u00e0 Sanitaria Locale \u2010 IRCCS di Reggio Emilia Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Zorzi","sequence":"additional","affiliation":[{"name":"Veneto Tumour Registry Azienda Zero Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Frayle","sequence":"additional","affiliation":[{"name":"Immunology and Diagnostic Molecular Oncology Unit Veneto Institute of Oncology IOV\u2010IRCCS Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Passamonti","sequence":"additional","affiliation":[{"name":"Laboratorio Unico di Screening USL Umbria 1 Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Sartori","sequence":"additional","affiliation":[{"name":"Laboratorio citologia cervico\u2010vaginale Azienda Unit\u00e0 Sanitaria Locale \u2010 IRCCS di Reggio Emilia Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Bulletti","sequence":"additional","affiliation":[{"name":"Cancer Screening Unit Azienda Unit\u00e0 Sanitaria Locale \u2010 IRCCS di Reggio Emilia Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Fodero","sequence":"additional","affiliation":[{"name":"Laboratorio citologia cervico\u2010vaginale Azienda Unit\u00e0 Sanitaria Locale \u2010 IRCCS di Reggio Emilia Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Cesarini","sequence":"additional","affiliation":[{"name":"Laboratorio Unico di Screening USL Umbria 1 Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Faggiano","sequence":"additional","affiliation":[{"name":"Cancer Screening Unit Azienda Unit\u00e0 Sanitaria Locale \u2010 IRCCS di Reggio Emilia Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7201-9374","authenticated-orcid":false,"given":"A","family":"Del Mistro","sequence":"additional","affiliation":[{"name":"Immunology and Diagnostic Molecular Oncology Unit Veneto Institute of Oncology IOV\u2010IRCCS Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,12]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"BruniL AlberoG SerranoB MenaM G\u00f3mezD Mu\u00f1ozJ et al.ICO HPV Information Centre on HPV and Cancer (HPV Information Centre). 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