{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T23:13:31Z","timestamp":1779923611934,"version":"3.53.1"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T00:00:00Z","timestamp":1611532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Phaeochromocytoma and paraganglioma (PPGL) in pregnancy, if not diagnosed antepartum, pose a high risk for mother and child.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the clinical clues of antepartum and postpartum\/postmortem diagnosis of PPGL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Search strategy<\/jats:title><jats:p>Case reports on PPGL in pregnancy published between 1 January 1988 and 30 June 2019 in English, German, Dutch or French.<\/jats:p><\/jats:sec><jats:sec><jats:title>Selection criteria<\/jats:title><jats:p>Case reports containing a predefined minimum of clinical data on PPGL and pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data collection and analysis<\/jats:title><jats:p>Two authors independently performed data extraction and assessed data quality. We calculated odds ratios (OR) (with 95% confidence intervals) and used uni\u2010 and multivariable logistic regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main results<\/jats:title><jats:p>Maternal and fetal\/neonatal mortalities were 9.0% (18\/200) and 14.2% (29\/204), respectively. Maternal mortality was 42\u2010fold higher with PPGL diagnosed postpartum\/postmortem (17\/58; 29.3%) than antepartum (1\/142; 0.7%) (adjusted OR 45.9, 95% CI 5.67\u2013370, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0003). Offspring mortality was 2.6\u2010fold higher with PPGL diagnosed postpartum\/postmortem than antepartum (OR 3.1, 95% CI 1.38\u20136.91, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0044). Hypertension at admission (OR 2.29, 95% CI 1.12\u20134.68, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.022), sweating (OR 3.14, 95% CI 1.29\u20137.63, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.014) and a history of PPGL, a known PPGL\u2010associated gene mutation or adrenal mass (OR 8.87, 95% CI 1.89\u201341.64, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0056) were independent factors of antepartum diagnosis. Acute onset of symptoms (OR 8.49, 95% CI 3.52\u201320.5, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001), initial diagnosis of pre\u2010eclampsia (OR 6.34, 95% CI 2.60\u201315.5, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001), admission for obstetric care (OR 10.71, 95% CI 2.70\u201342.45, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0007) and maternal tachycardia (OR 2.72, 95% CI 1.26\u20135.85, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.011) were independent factors of postpartum diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Several clinical clues can assist clinicians in considering an antenatal diagnosis of PPGL in pregnancy, thus potentially improving outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Systematic review of 204 pregnant patients with phaeochromocytoma identified clinical clues for a timely antepartum diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.16635","type":"journal-article","created":{"date-parts":[[2020,12,20]],"date-time":"2020-12-20T18:26:44Z","timestamp":1608488804000},"page":"1264-1272","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Pregnancy and phaeochromocytoma\/paraganglioma: clinical clues affecting diagnosis and outcome \u2013 a systematic review"],"prefix":"10.1111","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9333-5499","authenticated-orcid":false,"given":"K","family":"Langton","sequence":"first","affiliation":[{"name":"Institute of Clinical Chemistry and Laboratory Medicine University Hospital Carl Gustav Carus Dresden Germany"},{"name":"Medical Faculty Technical University Dresden Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Tufton","sequence":"additional","affiliation":[{"name":"Department of Endocrinology St Bartholomew\u2019s Hospital Bart\u2019s Health NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Akker","sequence":"additional","affiliation":[{"name":"Department of Endocrinology St Bartholomew\u2019s Hospital Bart\u2019s Health NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Deinum","sequence":"additional","affiliation":[{"name":"Medical Faculty Technical University Dresden Dresden Germany"},{"name":"Department of Medicine III University Hospital Carl Gustav Carus Dresden Germany"},{"name":"Department of Internal Medicine Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Eisenhofer","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry and Laboratory Medicine University Hospital Carl Gustav Carus Dresden Germany"},{"name":"Medical Faculty Technical University Dresden 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