{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:40:32Z","timestamp":1762868432090,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T00:00:00Z","timestamp":1615939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the contribution of maternal blood detection of IGFBP\u20101 for the diagnosis of amniotic\u2010fluid embolism in clinical daily practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A retrospective multicentre cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Three tertiary care obstetric units in France.<\/jats:p><\/jats:sec><jats:sec><jats:title>Sample<\/jats:title><jats:p>Data of 86 women for whom amniotic\u2010fluid embolism had been suspected and maternal serum detection of IGFBP\u20101 had been performed between 2011 and 2019 were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The criteria defined by the United Kingdom Obstetric Surveillance System (UKOSS) were used for the retrospective diagnosis of amniotic\u2010fluid embolism. The more structured definition proposed by the Society for Maternal\u2010Fetal Medicine and the Amniotic Fluid Embolism Foundation (SMFM) was also used as secondary endpoint.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Agreements between biological and clinical assessments were tested. The performance of blood detection of IGFBP\u20101 for the diagnosis of amniotic\u2010fluid embolism according to the UKOSS criteria, and to the SMFM definition, was also assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was only slight agreement between clinical and laboratory diagnosis of amniotic\u2010fluid embolism (Cohen\u2019s Kappa coefficient: 0.04). Blood detection of IGFBP\u20101 had a sensitivity of 16%, a specificity of 88%, a positive and a negative likelihood ratio of 1.3 and 0.95, respectively, and a positive and a negative predictive value of 58 and 50%, respectively, for the diagnosis of amniotic\u2010fluid embolism based on the UKOSS criteria. The use of the more structured SMFM definition of amniotic\u2010fluid embolism did not substantially change the results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results question the usefulness of blood detection of IGFBP\u20101 for the early diagnosis of amniotic\u2010fluid embolism in daily clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>This retrospective multicentre study questions the contribution of IGFBP\u20101 detection for the diagnosis of AFE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.16672","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T04:19:36Z","timestamp":1613621976000},"page":"1966-1973","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Contribution of blood detection of insulin\u2010like growth factor binding protein\u20101 for the diagnosis of amniotic\u2010fluid embolism: a retrospective multicentre cohort study"],"prefix":"10.1111","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5900-4194","authenticated-orcid":false,"given":"L","family":"Bouvet","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Femme M\u00e8re Enfant Hospital Hospices Civils de Lyon Bron France"},{"name":"University of Lyon Claude Bernard Lyon 1 University Villeurbanne France"},{"name":"APCSe VetAgro Sup UPSP 2016.A101 Marcy l\u2019Etoile France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Gariel","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Femme M\u00e8re Enfant Hospital Hospices Civils de Lyon Bron France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Charvet","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Femme M\u00e8re Enfant Hospital 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