{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:41:18Z","timestamp":1787013678196,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2021,6,27]],"date-time":"2021-06-27T00:00:00Z","timestamp":1624752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To study whether serum estradiol (E2) levels prior to progesterone administration in the artificial endometrial preparation (AEP) of frozen\u2013thawed blastocyst transfer affect the live birth rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Tertiary\u2010care academic medical centre.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>\n                      A total of 3857 frozen\u2013thawed blastocyst transfer cycles were divided into three groups: &lt;200\u2009pg\/ml (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091676); 200\u2013399\u2009pg\/ml (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091296); and \u2265400\u2009pg\/ml (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009885), based on the 25th (182.3\u2009pg\/ml) and 75th percentile (390.2\u2009pg\/ml) of serum E2 level prior to progesterone administration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Univariable and multivariable logistic regression analysis was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measures<\/jats:title>\n                    <jats:p>\n                      The primary outcome of the study was the live birth rate and the secondary outcomes included clinical pregnancy rate, pregnancy loss rate, neonatal birthweight,\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010score, and small for gestational age (SGA).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with the reference group, accounting for major covariates, the live birth rate significantly decreased in the \u2018\u2265400\u2009pg\/ml\u2019 group (adjusted OR\u20090.71, 95%\u2009CI 0.59\u20130.85). Compared with the reference group, there was an association between the E2 level in the \u2018\u2265400\u2009pg\/ml\u2019 group and a decrease in the clinical pregnancy rate (adjusted OR\u20090.74, 95%\u2009CI 0.61\u20130.89). Compared with the reference group, the pregnancy loss rate significantly increased in the \u2018\u2265400\u2009pg\/ml\u2019 group (adjusted OR\u20091.45, 95%\u2009CI 1.08\u20131.93). The E2 levels did not affect neonatal birthweight,\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010score, and SGA among singletons.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>High serum E2 levels prior to progesterone administration in AEP are associated with a decreased live birth rate after frozen\u2013thawed blastocyst transfer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Tweetable abstract<\/jats:title>\n                    <jats:p>High serum E2 levels prior to progesterone administration in artificial FET are associated with a decreased live birth rate after frozen\u2013thawed blastocyst transfer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1471-0528.16777","type":"journal-article","created":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T07:52:44Z","timestamp":1622188364000},"page":"2092-2100","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Association between serum estradiol levels prior to progesterone administration in artificial frozen\u2013thawed blastocyst transfer cycles and live birth rate: a retrospective study"],"prefix":"10.1111","volume":"128","author":[{"given":"R","family":"Zhou","sequence":"first","affiliation":[{"name":"Center for Reproductive Medicine Guangdong Women and Children Hospital Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine Guangdong Women and Children Hospital Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Huang","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine Guangdong Women and Children Hospital Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Zhu","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine Guangdong Women and Children Hospital Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Dong","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine Guangdong Women and Children Hospital Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine Guangdong Women and Children Hospital Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine Guangdong Women and Children Hospital Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine Guangdong Women and Children Hospital Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.06.010"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex264"},{"key":"e_1_2_7_4_1","first-page":"Cd003414","article-title":"Cycle regimens for frozen\u2010thawed embryo transfer","volume":"7","author":"Ghobara T","year":"2017","journal-title":"Cochrane Database Syst 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