{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:40:59Z","timestamp":1787164859716,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T00:00:00Z","timestamp":1625443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000664","name":"Health Technology Assessment Programme","doi-asserted-by":"publisher","award":["08\/53\/22"],"award-info":[{"award-number":["08\/53\/22"]}],"id":[{"id":"10.13039\/501100000664","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the cost\u2010effectiveness of uterine artery embolisation (UAE) and myomectomy for women with symptomatic uterine fibroids wishing to avoid hysterectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Economic evaluation alongside the FEMME randomised controlled trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>29 UK hospitals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>Premenopausal women who had symptomatic uterine fibroids amenable to UAE or myomectomy wishing to avoid hysterectomy. 254 women were randomised to UAE (127) and myomectomy (127).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A within\u2010trial cost\u2013utility analysis was conducted from the perspective of the UK NHS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measures<\/jats:title>\n                    <jats:p>Quality\u2010adjusted life years (QALYs) measured using the EuroQoL EQ\u20105D\u20103L, combined with costs to estimate cost\u2010effectiveness over 2 and 4\u00a0years of follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Over a 2\u2010year time horizon, UAE was associated with higher mean costs (difference \u00a3645; 95% CI \u22121381 to 2580) and lower QALYs (difference \u22120.09; 95% CI \u22120.11 to \u22120.04) when compared with myomectomy. Similar results were observed over the 4\u2010year time horizon. Thus, UAE was dominated by myomectomy. Results of the sensitivity analyses were consistent with the base case results for both years. Over 2\u00a0years, UAE was associated with higher costs (difference \u00a3456; 95% CI \u22121823 to 3164) and lower QALYs (difference \u22120.06; 95% CI \u22120.11 to \u22120.02).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Myomectomy is a cost\u2010effective option for the treatment of uterine fibroids. The differences in costs and QALYs are small. Women should be fully informed and have the option to choose between the two procedures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Tweetable abstract<\/jats:title>\n                    <jats:p>Fully informed women with uterine fibroids should have a choice between uterine artery embolisation or myomectomy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1471-0528.16781","type":"journal-article","created":{"date-parts":[[2021,5,30]],"date-time":"2021-05-30T06:17:48Z","timestamp":1622355468000},"page":"1793-1802","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Uterine artery embolisation or myomectomy for women with uterine fibroids wishing to avoid hysterectomy: a cost\u2013utility analysis of the FEMME trial"],"prefix":"10.1111","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9133-3094","authenticated-orcid":false,"given":"D","family":"Rana","sequence":"first","affiliation":[{"name":"Health Economics and Health Technology Assessment (HEHTA) Institute of Health &amp; Wellbeing University of Glasgow Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Wu","sequence":"additional","affiliation":[{"name":"Health Economics and Health Technology Assessment (HEHTA) Institute of Health &amp; Wellbeing University of Glasgow Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6713-0913","authenticated-orcid":false,"given":"V","family":"Cheed","sequence":"additional","affiliation":[{"name":"Birmingham Clinical Trials Unit University of Birmingham Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LJ","family":"Middleton","sequence":"additional","affiliation":[{"name":"Birmingham Clinical Trials Unit University of Birmingham Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Moss","sequence":"additional","affiliation":[{"name":"School of Medicine University of Glasgow Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u2010A","family":"Lumsden","sequence":"additional","affiliation":[{"name":"School of Medicine University of Glasgow Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"McKinnon","sequence":"additional","affiliation":[{"name":"Birmingham Clinical Trials Unit University of Birmingham Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3324-6771","authenticated-orcid":false,"given":"J","family":"Daniels","sequence":"additional","affiliation":[{"name":"Nottingham Clinical Trials Unit University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Sirkeci","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Whipps Cross Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Manyonda","sequence":"additional","affiliation":[{"name":"Department of Gynaecology St George\u2019s Hospital and Medical School London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A\u2010M","family":"Belli","sequence":"additional","affiliation":[{"name":"Department of Radiology St\u00a0George\u2019s Hospital and Medical School London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"McPherson","sequence":"additional","affiliation":[{"name":"Department of Primary Care University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the FEMME Trial Collaborative Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,5]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Magnetic Resonance Image\u2010guided Transcutaneous Focused Ultrasound for Uterine Fibroids. 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