{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:25:55Z","timestamp":1747182355638,"version":"3.40.5"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T00:00:00Z","timestamp":1627862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872634"],"award-info":[{"award-number":["81872634"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the association between the vaginal microenvironment and fecundability among women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Register\u2010based nationwide cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Chinese National Free Pre\u2010conception Check\u2010up Project from 2015 to 2018.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Our study included a total of 3\u2009388\u2009554 eligible women who were attempting to become pregnant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We assessed the vaginal microenvironment at baseline by considering four indices: vaginal pH, clue cell examination, whiff test and vaginal cleanliness grading. If any of these indicators was abnormal, the vaginal microenvironment was defined as poor. Propensity score matching was used to control for potential confounders and reduce bias. Logistic models were used to estimate the fecundability odds ratios (FORs) after adjustment for covariates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Achievement of a pregnancy within 1\u2009year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the total study population, 379\u2009718 women (11.2%) had a poor vaginal microenvironment and their pregnancy rate after 1\u2009year was significantly lower than the group with a normal microenvironment (71.8% versus 76.1%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). After adjusting for potential confounders, the women with a poor vaginal microenvironment were associated with a 9% reduction in fecundability compared with the normal microenvironment group (FOR 0.91, 95% CI 0.90\u20130.92). The adverse effects of a poor vaginal microenvironment were stronger among multipara (FOR 0.89, 95% CI 0.87\u20130.90) or women with irregular menstruation (FOR 0.86, 95% CI 0.84\u20130.89).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There was a negative association between a poor vaginal microenvironment and the fecundability of women. These findings highlight the significance of assessing the vaginal microenvironment during pre\u2010pregnancy health examinations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Women with a poor vaginal microenvironment were associated with a reduction in fecundability.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.16843","type":"journal-article","created":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T08:44:33Z","timestamp":1626252273000},"page":"43-51","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The association between the vaginal microenvironment and fecundability: a register\u2010based cohort study among Chinese women"],"prefix":"10.1111","volume":"129","author":[{"given":"X","family":"Hong","sequence":"first","affiliation":[{"name":"Key Laboratory of Environmental Medicine and Engineering of Ministry of Education Department of Epidemiology and Health Statistics 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