{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T22:35:40Z","timestamp":1787956540624,"version":"build-2784847793"},"reference-count":29,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T00:00:00Z","timestamp":1632182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate whether locally applied vaginal estrogen affects prolapse\u2010associated complaints compared with placebo treatment in postmenopausal women prior to surgical prolapse repair.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Randomised, double\u2010masked, placebo\u2010controlled, multicentre study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Urogynaecology unit at the Medical University of Vienna and University Hospital of Tulln.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Postmenopausal women with symptomatic pelvic organ prolapse and planned surgical prolapse repair.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Women were randomly assigned local estrogen cream or placebo cream 6\u2009weeks preoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>The primary outcome was differences in subjective prolapse\u2010associated complaints after 6\u2009weeks of treatment prior to surgery, assessed with the comprehensive German pelvic floor questionnaire. Secondary outcomes included differences in other pelvic floor\u2010associated complaints (bladder, bowel or sexual function).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 120 women randomised, 103 (86%) remained for the final analysis. After 6\u2009weeks of treatment the prolapse domain score did not differ between the estrogen and the placebo groups (4.4\u2009\u00b1\u20090.19 versus 4.6\u2009\u00b1\u20090.19; mean difference, \u22120.21; 95%\u2009CI \u22120.74 to 0.33; <jats:italic>P<\/jats:italic>\u2009=\u20090.445). Multivariate analysis, including only women receiving the intervention, showed that none of the confounding factors modified the response to estradiol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results demonstrate that preoperative locally applied estrogen does not ameliorate prolapse\u2010associated symptoms in postmenopausal women with symptomatic pelvic organ prolapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Preoperative local estrogen does not ameliorate prolapse\u2010associated symptoms in postmenopausal women with pelvic organ prolapse.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.16894","type":"journal-article","created":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T18:22:36Z","timestamp":1630434156000},"page":"2200-2208","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Does preoperative locally applied estrogen treatment facilitate prolapse\u2010associated symptoms in postmenopausal women with symptomatic pelvic organ prolapse? 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