{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T18:30:21Z","timestamp":1776709821131,"version":"3.51.2"},"reference-count":19,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T00:00:00Z","timestamp":1632700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To report complication rates following prolapse surgery using polypropylene mesh inlay, polypropylene mesh kit, biological collagen xenografts and native tissue repairs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Secondary analysis of the PROSPECT randomised controlled trial and cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Thirty\u2010five UK hospitals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>A total of 2632 women undergoing anterior and\/or posterior vaginal prolapse repair.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Event rates were calculated for all complications. Analysis was by treatment received.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>IUGA\/ICS classification of complications and validated patient reported outcome measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, 8.4% of women had \u2018generic\u2019 pain\/discomfort; at 2\u2009years following surgery, there was an improvement in all four groups; however, 3.0% of women developed de novo extreme generic pain. At 24\u2009months de novo vaginal tightness occurred in 1.6% of native tissue, 1.2% of biological xenograft, 0.3% of mesh inlay and 3.6% of mesh kit. Severe dyspareunia occurred in 4.8% of native tissue, 4.2% of biological xenograft, 3.4% of mesh inlay repairs and 13.0% of mesh kits. De novo severe dyspareunia occurred in 3.5% of native tissue, 3.5% of biological xenograft, 1.4% of mesh inlays and 4.8% of mesh kits. Complications requiring re\u2010admission to hospital, unrelated to mesh, affected 1 in 24 women; the most common reasons for re\u2010admission were vaginal adhesions, urinary retention, infection and constipation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This is the first study to address the complications of vaginal mesh used for prolapse surgery alongside data from both native tissue and biological xenograft. It demonstrates the complexity of assessing pain and that all types of prolapse surgery have low surgical morbidity and a low rate of severe complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>A prospective study of 2362 women undergoing vaginal mesh, xenograft or native tissue repair found low surgical morbidity and low rates of severe complications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.16897","type":"journal-article","created":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T18:44:31Z","timestamp":1630608271000},"page":"2180-2189","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["How common are complications following polypropylene mesh, biological xenograft and native tissue surgery for pelvic organ prolapse? A secondary analysis from the PROSPECT trial"],"prefix":"10.1111","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6029-7948","authenticated-orcid":false,"given":"FM","family":"Reid","sequence":"first","affiliation":[{"name":"The Warrell Unit Saint Mary\u2019s Hospital Manchester University NHS Foundation Trust Manchester Academic Health Science Centre Manchester UK"},{"name":"Faculty of Medical &amp; Human Sciences Manchester Academic Health Science Centre Institute of Human Development University of Manchester Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4172-4702","authenticated-orcid":false,"given":"A","family":"Elders","sequence":"additional","affiliation":[{"name":"NMAHP Research Unit Glasgow Caledonian University Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Breeman","sequence":"additional","affiliation":[{"name":"Health Services Research Unit Centre for Healthcare Randomised Trial University of Aberdeen Aberdeen UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RM","family":"Freeman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Plymouth Hospitals NHS Trust Plymouth UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the PROSPECT study group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,27]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Vaginal Mesh: High Vigilance Restriction Period: Immediate Action Required, All Cases Should be Postponed If it is Clinically Safe to Do So","author":"NHS Improvement and NHS England","year":"2018"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.12.066"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-015-2913-4"},{"key":"e_1_2_7_5_1","volume-title":"The Report of the Independent Medicines and Medical Devices Safety Review","author":"First Do No Harm","year":"2020"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta20950"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31596-3"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.16197"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-010-1324-9"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-011-1659-x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-013-2257-x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199711000-00002"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2008.01903.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)00348-4"},{"key":"e_1_2_7_15_1","first-page":"10","article-title":"The standardization of terminology of female pelvic organ prolapse and pelvic floor dysfunction","volume":"175","author":"Bump RC","year":"1996","journal-title":"Obstet Gynecol"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-013-2229-1"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2006.06.023"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-11821-w"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)36740-X"},{"key":"e_1_2_7_20_1","first-page":"444","article-title":"Urinary incontinence in women, without manifest injury to the bladder","volume":"18","author":"Kelly H","year":"1914","journal-title":"Surg Gynecol Obstet"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; 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