{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:58:10Z","timestamp":1787961490725,"version":"build-2784847793"},"reference-count":77,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T00:00:00Z","timestamp":1633305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1194248"],"award-info":[{"award-number":["1194248"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2022,2]]},"abstract":"\n Background<\/jats:title>\n \n Hypertensive disorders account for 14% of global maternal deaths. Magnesium sulphate (MgSO\n 4<\/jats:sub>\n ) is recommended for prevention and treatment of pre\u2010eclampsia\/eclampsia. However, MgSO\n 4<\/jats:sub>\n remains underused, particularly in low\u2010 and middle\u2010income countries (LMICs).\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n This qualitative evidence synthesis explores perceptions and experiences of healthcare providers, administrators and policy\u2010makers regarding factors affecting use of MgSO\n 4<\/jats:sub>\n to prevent or treat pre\u2010eclampsia\/eclampsia.\n <\/jats:p>\n <\/jats:sec>\n \n Search strategy<\/jats:title>\n We searched MEDLINE, EMBASE, Emcare, CINAHL, Global Health and Global Index Medicus, and grey literature for studies published between January 1995 and June 2021.<\/jats:p>\n <\/jats:sec>\n \n Selection criteria<\/jats:title>\n \n Primary qualitative and mixed\u2010methods studies on factors affecting use of MgSO\n 4<\/jats:sub>\n in healthcare settings, from the perspectives of healthcare providers, administrators and policy\u2010makers, were eligible for inclusion.\n <\/jats:p>\n <\/jats:sec>\n \n Data collection and analysis<\/jats:title>\n \n We applied a thematic synthesis approach to analysis, using COM\u2010B behaviour change theory to map factors affecting appropriate use of MgSO\n 4<\/jats:sub>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Main results<\/jats:title>\n \n We included 22 studies, predominantly from LMICs. Key themes included provider competence and confidence administering MgSO\n 4<\/jats:sub>\n (attitudes and beliefs, complexities of administering, knowledge and experience), capability of health systems to ensure MgSO\n 4<\/jats:sub>\n availability at point of use (availability, resourcing and pathways to care) and knowledge translation (dissemination of research and recommendations). Within each COM\u2010B domain, we mapped facilitators and barriers to physical and psychological capability, physical and social opportunity, and how the interplay between these domains influences motivation.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n These findings can inform policy and guideline development and improve implementation of MgSO\n 4<\/jats:sub>\n in clinical care. Such action is needed to ensure this life\u2010saving treatment is widely available and appropriately used.\n <\/jats:p>\n <\/jats:sec>\n \n Tweetable abstract<\/jats:title>\n \n Global qualitative review identifies factors affecting underutilisation of MgSO\n 4<\/jats:sub>\n for pre\u2010eclampsia and eclampsia.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/1471-0528.16913","type":"journal-article","created":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T11:50:09Z","timestamp":1631620209000},"page":"379-391","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Factors affecting use of magnesium sulphate for pre\u2010eclampsia or eclampsia: a qualitative evidence synthesis"],"prefix":"10.1111","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2106-4746","authenticated-orcid":false,"given":"KE","family":"Eddy","sequence":"first","affiliation":[{"name":"Gender and Women's Health Unit Centre for Health Equity School of Population and Global Health University of Melbourne Carlton VIC Australia"},{"name":"Maternal, Child, and Adolescent Health Programme Burnet Institute Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3214-7096","authenticated-orcid":false,"given":"JP","family":"Vogel","sequence":"additional","affiliation":[{"name":"Maternal, Child, and Adolescent Health Programme Burnet Institute Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7831-2336","authenticated-orcid":false,"given":"RI","family":"Zahroh","sequence":"additional","affiliation":[{"name":"Gender and Women's Health Unit Centre for Health Equity School of Population and Global Health University of Melbourne Carlton VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4179-4682","authenticated-orcid":false,"given":"MA","family":"Bohren","sequence":"additional","affiliation":[{"name":"Gender and Women's Health Unit Centre for Health Equity School of Population and Global Health University of Melbourne Carlton VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2013.05.005"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091198"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1596\/978-0-8213-6133-7"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(14)70227-X"},{"key":"e_1_2_7_6_1","volume-title":"WHO Recommendations for Prevention and Treatment of Pre\u2010eclampsia and Eclampsia","author":"World Health Organization","year":"2011"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)91034-4"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08778-0"},{"issue":"12","key":"e_1_2_7_9_1","first-page":"CD000127","article-title":"Magnesium sulphate versus diazepam for eclampsia","author":"Duley L","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"issue":"10","key":"e_1_2_7_10_1","first-page":"CD000128","article-title":"Magnesium sulphate versus phenytoin for eclampsia","author":"Duley L","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"issue":"11","key":"e_1_2_7_11_1","first-page":"CD000025","article-title":"Magnesium sulphate and other anticonvulsants for women with pre\u2010eclampsia","author":"Duley L","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002960.pub2"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2005.00785.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3329\/jhpn.v31i1.14753"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-015-0554-8"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.01166.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.01165.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002988"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.331.7519.765"},{"key":"e_1_2_7_20_1","volume-title":"World Health Organization: Model List of Essential Medicines","author":"World Health Organization","year":"2019"},{"key":"e_1_2_7_21_1","volume-title":"Managing Complications in Pregnancy and Childbirth: A Guide for Midwives and Doctors","author":"World Health Organization","year":"2017"},{"issue":"8","key":"e_1_2_7_22_1","first-page":"CD007388","article-title":"Alternative magnesium sulphate regimens for women with pre\u2010eclampsia and eclampsia","author":"Duley L","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12807"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.06.037911"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0189966"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12978-018-0531-6"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14400"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12978-018-0532-5"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-016-1055-0"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059158"},{"key":"e_1_2_7_31_1","volume-title":"EPOC Qualitative Evidence Syntheses: Protocol and Review Template (version 1.1)","author":"Glenton C","year":"2020"},{"key":"e_1_2_7_32_1","volume-title":"PROSPERO [Factors Affecting use of Magnesium Sulphate for Pre\u2010eclampsia or Eclampsia: A Qualitative Evidence Synthesis]","author":"National Institute for Health Research"},{"key":"e_1_2_7_33_1","volume-title":"Critical Appraisal Skills Programme","author":"CASP UK","year":"2020"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012449"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13012-017-0690-9"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-8-45"},{"key":"e_1_2_7_37_1","volume-title":"NVivo","author":"QSR International Pty Ltd","year":"2020"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-5908-6-42"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13012-017-0688-3"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13012-017-0691-8"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13012-017-0692-7"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13012-017-0693-6"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13012-017-0689-2"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012876.pub2"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-5-68"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2016.06.001"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.31899\/rh11.1005"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.31899\/rh11.1024"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.31899\/rh11.1011"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.31899\/rh11.1010"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2012.11.015"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.31899\/rh9.1000"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.31899\/rh9.1026"},{"key":"e_1_2_7_54_1","article-title":"The use of magnesium sulphate in the management of severe preeclampsia and eclampsia in Bayelsa State, Nigeria","volume":"21","author":"Alabintei O","year":"2021","journal-title":"J Gynecol Womens Health"},{"key":"e_1_2_7_55_1","first-page":"17","article-title":"Assessment of compliance with national guidelines on the management of severe preeclampsia and eclampsia in public health facilities in Bayelsa State","volume":"5","author":"Alabintei O","year":"2021","journal-title":"Asian Res J Gynaecol Obstet"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1186\/1478-4505-7-31"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2011.07.016"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0172602"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12978-016-0215-z"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S223029"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12978-016-0219-8"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-019-2186-x"},{"key":"e_1_2_7_63_1","volume-title":"Expanding Use of Magnesium Sulfate for Treatment of Pre\u2010eclampsia and Eclampsia: Building Towards Scale in Nigeria","author":"Danmusa S","year":"2014"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2008.02.002"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-10-340"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.9745\/GHSP-D-14-00034"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-5-421"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-13-186"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12222"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.4103\/1596-3519.56232"},{"key":"e_1_2_7_71_1","doi-asserted-by":"crossref","first-page":"e0213491","DOI":"10.1371\/journal.pone.0213491","article-title":"Magnesium sulphate and anti\u2010shock garment: a knowledge, availability and utilization study at the Primary Health Care Level in Western Nigeria","volume":"3","author":"Duduyemi AO","year":"2019","journal-title":"PLoS One"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2009.07.017"},{"key":"e_1_2_7_73_1","first-page":"CD011558","article-title":"Factors that influence the provision of intrapartum and postnatal care by skilled birth attendants in low\u2010 and middle\u2010income countries: a qualitative evidence synthesis","volume":"11","author":"Munabi\u2010Babigumira S","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2016.02.017"},{"key":"e_1_2_7_75_1","volume-title":"WHO Recommendations: Optimizing Health Worker Roles to Improve Access to Key Maternal and Newborn Health Interventions through Task Shifting","author":"World Health Organization","year":"2012"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-13-34"},{"issue":"10","key":"e_1_2_7_77_1","article-title":"Magnesium sulphate and other anticonvulsants for women with pre\u2010eclampsia","author":"Duley L","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(15)30662-9"}],"container-title":["BJOG: An International Journal of Obstetrics & Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.16913","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1471-0528.16913","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.16913","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T22:30:36Z","timestamp":1692484236000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/1471-0528.16913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,4]]},"references-count":77,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1111\/1471-0528.16913"],"URL":"https:\/\/doi.org\/10.1111\/1471-0528.16913","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,4]]},"assertion":[{"value":"2021-07-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}