{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:41:18Z","timestamp":1787013678144,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T00:00:00Z","timestamp":1633305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate current practice and outcomes of pregnancy in women previously diagnosed with Budd\u2013Chiari syndrome and\/or portal vein thrombosis, with and without concomitant portal hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design and setting<\/jats:title>\n                    <jats:p>Multicentre retrospective cohort study between 2008 and 2021.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>Women who conceived in the predefined period after the diagnosis of Budd\u2013Chiari syndrome and\/or portal vein thrombosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and main outcome measures<\/jats:title>\n                    <jats:p>We collected data on diagnosis and clinical features. The primary outcomes were maternal mortality and live birth rate. Secondary outcomes included maternal, neonatal and obstetric complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Forty\u2010five women (12 Budd\u2013Chiari syndrome, 33 portal vein thrombosis; 76 pregnancies) were included. Underlying prothrombotic disorders were present in 23 of the 45 women (51%). Thirty\u2010eight women (84%) received low\u2010molecular\u2010weight heparin during pregnancy. Of 45 first pregnancies, 11 (24%) ended in pregnancy loss and 34 (76%) resulted in live birth of which 27 were at term (79% of live births and 60% of pregnancies). No maternal deaths were observed; one woman developed pulmonary embolism during pregnancy and two women (4%) had variceal bleeding requiring intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The high number of term live births (79%) and lower than expected risk of pregnancy\u2010related maternal and neonatal morbidity in our cohort suggest that Budd\u2013Chiari syndrome and\/or portal vein thrombosis should not be considered as an absolute contraindication for pregnancy. Individualised, nuanced counselling and a multidisciplinary pregnancy surveillance approach are essential in this patient population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Tweetable abstract<\/jats:title>\n                    <jats:p>Budd\u2013Chiari syndrome and\/or portal vein thrombosis should not be considered as an absolute contraindication for pregnancy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1471-0528.16915","type":"journal-article","created":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T12:09:55Z","timestamp":1631621395000},"page":"608-617","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Pregnancy outcomes in women with Budd\u2013Chiari syndrome or portal vein thrombosis\u2009\u2013\u2009a multicentre retrospective cohort study"],"prefix":"10.1111","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0488-7529","authenticated-orcid":false,"given":"HMG","family":"Wiegers","sequence":"first","affiliation":[{"name":"Department of Vascular Medicine Amsterdam UMC University of Amsterdam Amsterdam Cardiovascular Sciences Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9340-8771","authenticated-orcid":false,"given":"EN","family":"Hamuly\u00e1k","sequence":"additional","affiliation":[{"name":"Department of Vascular Medicine Amsterdam UMC University of Amsterdam Amsterdam Cardiovascular Sciences Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8411-2816","authenticated-orcid":false,"given":"SE","family":"Damhuis","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Amsterdam UMC University of Amsterdam Amsterdam Reproduction &amp; Development Research Institute Amsterdam The Netherlands"},{"name":"Department of Obstetrics and Gynaecology University Medical Centre Groningen University of Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JR","family":"van Duuren","sequence":"additional","affiliation":[{"name":"Department of Vascular Medicine Amsterdam UMC University of Amsterdam Amsterdam Cardiovascular Sciences Amsterdam The Netherlands"},{"name":"Department of Obstetrics and Gynaecology Amsterdam UMC University of Amsterdam Amsterdam Reproduction &amp; Development Research Institute Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2804-1165","authenticated-orcid":false,"given":"S","family":"Darwish Murad","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Erasmus University Medical Centre Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5282-5520","authenticated-orcid":false,"given":"LJJ","family":"Scheres","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine &amp; Radboud Institute of Health Sciences (RIHS) Radboud University Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3915-8609","authenticated-orcid":false,"given":"SJ","family":"Gordijn","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University Medical Centre Groningen University of Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3356-3910","authenticated-orcid":false,"given":"J","family":"Leentjens","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine &amp; Radboud Institute of Health Sciences (RIHS) Radboud University Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3191-9362","authenticated-orcid":false,"given":"JJ","family":"Duvekot","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Erasmus University Medical Centre Rotterdam Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MN","family":"Lauw","sequence":"additional","affiliation":[{"name":"Deparment of Haematology Erasmus University Medical Centre Rotterdam Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BA","family":"Hutten","sequence":"additional","affiliation":[{"name":"Departmentof Epidemiology and Data Science Amsterdam UMC University of Amsterdam Amsterdam Cardiovascular Sciences Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1006-6420","authenticated-orcid":false,"given":"S","family":"Middeldorp","sequence":"additional","affiliation":[{"name":"Department of Vascular Medicine Amsterdam UMC University of Amsterdam Amsterdam Cardiovascular Sciences Amsterdam The Netherlands"},{"name":"Department of Internal Medicine &amp; Radboud Institute of Health Sciences (RIHS) Radboud University Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7243-2115","authenticated-orcid":false,"given":"W","family":"Ganzevoort","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Amsterdam UMC University of Amsterdam Amsterdam Reproduction &amp; Development Research Institute Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2008.01838.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH16-10-0781"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-017-9810-5"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-3-200908040-00004"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-07-551515"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.07.040"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-09-376517"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2015.3184"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/839875"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.167577"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13552"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.02.028"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v9.i21.945"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2014.05.014"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.08.007"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.07.034"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2014.12.007"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2018.05.004"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-016-2740-8"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15884"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20591"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23259"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1407434"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-143-10-200511150-00006"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01307.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH08-04-0238"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2008.02921.x"},{"key":"e_1_2_6_29_1","volume-title":"Reducing the Risk of Venous Thromboembolism during Pregnancy and the Puerperium Pregnancy and the Puerperium","author":"RCOG","year":"2015"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000963"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2011.10.002"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-12-626739"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-09-728006"},{"key":"e_1_2_6_34_1","article-title":"Aspirin or heparin or both for improving pregnancy outcomes in women with persistent antiphospholipid antibodies and recurrent pregnancy loss","volume":"5","author":"Hamuly\u00e1k EN","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14697"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2013.11.012"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2010.01407.x"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.16915","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1471-0528.16915","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.16915","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T15:40:00Z","timestamp":1700062800000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/1471-0528.16915"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,4]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1111\/1471-0528.16915"],"URL":"https:\/\/doi.org\/10.1111\/1471-0528.16915","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.22541\/au.162126800.05949743\/v1","asserted-by":"object"}]},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,4]]},"assertion":[{"value":"2021-05-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}