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Random\u2010effects models were used to meta\u2010analyse the results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main results<\/jats:title><jats:p>Twenty studies met the inclusion criteria. The odds of delivering SGA babies increased with maternal asthma severity. Pregnant women with an asthma exacerbation had higher odds of delivering LBW babies and SGA babies, compared with pregnant women with asthma but without an exacerbation (pooled adjusted odds ratio [OR] 1.15, 95% CI 1.02\u20131.29 for LBW; number of studies with adjusted OR 3; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090%) (pooled adjusted OR 1.13, 95% CI 1.04\u20131.23 for SGA; number of studies with adjusted OR 4; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090%) and compared to pregnant women without asthma. Oral corticosteroids use during pregnancy was associated with increased odds of LBW, but not PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The available data suggest that maternal asthma severity and exacerbations are associated with increased odds of LBW and SGA babies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>A systematic review and meta\u2010analysis found that maternal asthma severity and exacerbations are associated with increased odds of delivering low birthweight and small\u2010for\u2010gestational\u2010age babies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.16968","type":"journal-article","created":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T18:39:43Z","timestamp":1634323183000},"page":"367-377","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Asthma severity and impact on perinatal outcomes: an updated systematic 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