{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:19:11Z","timestamp":1790518751674,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T00:00:00Z","timestamp":1637625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Evaluation of relevance and feasibility of universal newborn congenital cytomegalovirus infection (cCMVI) screening in saliva.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective, population\u2010based cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Clamart, France, 2016\u20132020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>All neonates born consecutively in our level III maternity unit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>CMV PCR in saliva for all neonates at birth, and, if positive, CMV PCR in urine to confirm or exclude cCMVI. Prospective and retrospective characterisation of maternal infections. ROC curve analysis to assess saliva PCR performances. Acceptability of screening among staff members evaluated by a survey.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Number of cCMVI neonates; number of expected and unexpected cCMVI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 15\u2009341 tested neonates, 63 had cCMVI (birth prevalence of 0.4%, 95% CI 0.3\u20130.5). In 50% of cases, maternal infection was a non\u2010primary infection (NPI) during pregnancy. cCMVI was expected or suspected (maternal primary infection [PI], antenatal or neonatal signs) in 24\/63 neonates (38%), and unexpected in 39\/63 neonates (62%). The best CMV saliva threshold to predict cCMVI was 356 (2.55 log)\u2009copies\/ml [95% CI 2.52 log\u20133.18 log], with an area under the ROC curve of 0.97. Over 90% of the 72 surveyed staff members reported that the screening was easy and quick. No parent refused the screening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Universal screening for cCMVI with CMV PCR on saliva samples is feasible and highly acceptable to parents and healthcare providers. Over half (62%) of the cases had no prenatal\/neonatal signs of cCMVI or a maternal history of CMV infection during pregnancy and would probably not have been diagnosed without universal screening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>In 62% of congenital cytomegalovirus infection cases, only universal neonatal screening in saliva can detect infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.16992","type":"journal-article","created":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T11:55:38Z","timestamp":1635854138000},"page":"291-299","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Universal newborn screening for congenital cytomegalovirus infection: feasibility and relevance in a French type\u2010III maternity cohort"],"prefix":"10.1111","volume":"129","author":[{"given":"E","family":"Letamendia\u2010Richard","sequence":"first","affiliation":[{"name":"Division of Pediatrics and Neonatal Critical Care Dept of Perinatal Medicine Paris Saclay University Hospital, APHP Clamart France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"P\u00e9rillaud\u2010Dubois","sequence":"additional","affiliation":[{"name":"IAME, INSERM U1137 Universit\u00e9 de Paris Paris France"},{"name":"Division of Virology Dept of Biology and Medical Genomics Sorbonne University Hospital, APHP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"de La Guillonni\u00e8re","sequence":"additional","affiliation":[{"name":"Division of Pediatrics and Neonatal Critical Care Dept of Perinatal Medicine Paris Saclay University Hospital, APHP Clamart France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Thouard","sequence":"additional","affiliation":[{"name":"Division of Virology Dept of Biology Genetics and PUI, Paris Saclay University Hospital, APHP Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A\u2010G","family":"Cordier","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynaecology Dept of Perinatal Medicine Paris Saclay University Hospital, APHP Clamart France"},{"name":"3PHM, U1139 INSERM Universit\u00e9 de Paris Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A\u2010M","family":"Roque\u2010Afonso","sequence":"additional","affiliation":[{"name":"Division of Virology Dept of Biology Genetics and PUI, Paris Saclay University Hospital, APHP Villejuif France"},{"name":"INSERM U1193 Universit\u00e9 Paris Saclay Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"de Luca","sequence":"additional","affiliation":[{"name":"Division of Pediatrics and Neonatal Critical Care Dept of Perinatal Medicine Paris Saclay University Hospital, APHP Clamart France"},{"name":"Pathophysiology and Therapeutic Innovation\u2013INSERM U999 Unit Universit\u00e9 Paris Saclay Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Benachi","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynaecology Dept of Perinatal Medicine Paris Saclay University Hospital, APHP Clamart France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Vauloup\u2010Fellous","sequence":"additional","affiliation":[{"name":"Division of Virology Dept of Biology Genetics and PUI, Paris Saclay University Hospital, APHP Villejuif France"},{"name":"INSERM U1193 Universit\u00e9 Paris Saclay Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.535"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.02.018"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2009.127"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0227143"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1404599"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/600882"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix337"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30143-3"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0368-2315(05)82710-3"},{"key":"e_1_2_7_11_1","unstructured":"HCSPPr\u00e9vention de l\u2019infection \u00e0 cytom\u00e9galovirus chez la femme enceinte et le nouveau\u2010n\u00e9. 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