{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:47:55Z","timestamp":1791488875777,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T00:00:00Z","timestamp":1670544000000},"content-version":"am","delay-in-days":345,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T00:00:00Z","timestamp":1640736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006190","name":"Research and Development","doi-asserted-by":"publisher","award":["2017YFC1001004"],"award-info":[{"award-number":["2017YFC1001004"]}],"id":[{"id":"10.13039\/100006190","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006190","name":"Research and Development","doi-asserted-by":"publisher","award":["2018YFC1003202"],"award-info":[{"award-number":["2018YFC1003202"]}],"id":[{"id":"10.13039\/100006190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the effect of dehydroepiandrosterone (DHEA) pre\u2010treatment before in vitro fertilization and embryo transfer (IVF\u2010ET) on the live birth rate in infertile women with poor ovarian response (POR) defined according to the Bologna criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A randomized, double\u2010blind, placebo\u2010controlled trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Nine reproductive medical centers in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>A total of 821 participants with POR defined according to the Bologna criteria were enrolled in the study between April 2016 and December 2018.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eligible participants were randomly assigned to receive either DHEA (<jats:italic>n<\/jats:italic>\u00a0=\u00a0410) or placebo (<jats:italic>n<\/jats:italic>\u00a0=\u00a0411) treatments for 4\u201312\u00a0weeks prior to IVF\u2010ET, in a 1:1 ratio.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Live birth rate after the first embryo transfer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010six (8.8%) of 410 women in the DHEA group and 37 (9.0%) of 411 women in the placebo group had a live birth, with no significant difference observed between groups (relative risk, 0.98, 95% CI, 0.63\u20131.51; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.911). There were no significant differences in the number of retrieved oocytes, and the rates of clinical pregnancy, pregnancy loss, and cumulative live births between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>DHEA administration prior to IVF\u2010ET had no beneficial effect on the live birth rate relative to placebo in women with POR defined according to the Bologna criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable Abstract<\/jats:title><jats:p>No benefit was found in poor ovarian responders who received DHEA administration prior to IVF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.17045","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T15:24:05Z","timestamp":1639063445000},"page":"1030-1038","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Effect of dehydroepiandrosterone administration before in\u00a0vitro fertilization on the live birth rate in poor ovarian responders according to the Bologna criteria: A randomised controlled trial"],"prefix":"10.1111","volume":"129","author":[{"given":"Ze","family":"Wang","sequence":"first","affiliation":[{"name":"Center for Reproductive Medicine Cheeloo College of Medicine Shandong University  Jinan China"},{"name":"The Key Laboratory of Reproductive Endocrinology of Ministry of Education National Research Center for Assisted Reproductive Technology and Reproductive Genetics  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aijun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine Affiliated Hospital of Jining Medical University  Jining China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongchu","family":"Bao","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine Yantai Yuhuangding Hospital  Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ancong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine Linyi People's Hospital  Linyi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Center for Reproductive Medicine Qilu Hospital of Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dena","family":"Xue","sequence":"additional","affiliation":[{"name":"Reproductive Hospital of Weifang Medical University  Weifang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifang","family":"Tan","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine The Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine Qingdao Women and Children's Hospital Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanye","family":"Wu","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine Linyi Maternal and Child Health Care Hospital  Linyi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi\u2010Jiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine Cheeloo College of Medicine Shandong University  Jinan China"},{"name":"The Key Laboratory of Reproductive Endocrinology of Ministry of Education National Research Center for Assisted Reproductive Technology and Reproductive Genetics  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7413-4031","authenticated-orcid":false,"given":"Yuhua","family":"Shi","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine Cheeloo College of Medicine Shandong University  Jinan China"},{"name":"The Key Laboratory of Reproductive Endocrinology of Ministry of Education National Research Center for Assisted Reproductive Technology and Reproductive Genetics  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,29]]},"reference":[{"issue":"12","key":"e_1_2_10_2_1","first-page":"2703","article-title":"Cumulative live birth rate: time for a consensus?","volume":"30","author":"Maheshwari A","year":"2015","journal-title":"Hum Reprod"},{"issue":"2","key":"e_1_2_10_3_1","first-page":"370","article-title":"Conventional ovarian stimulation and single embryo transfer for IVF\/ICSI. 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