{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:42:33Z","timestamp":1790401353506,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,2,13]],"date-time":"2022-02-13T00:00:00Z","timestamp":1644710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003123","name":"Fetal Medicine Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003123","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011102","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["FP7\u2010HEALTH\u20102013\u2010INNOVATION\u20102"],"award-info":[{"award-number":["FP7\u2010HEALTH\u20102013\u2010INNOVATION\u20102"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the predictive performance for preterm\u2010pre\u2010eclampsia (PE) in first\u2010trimester screening by serum placental growth factor (PlGF) versus pregnancy associated plasma protein\u2010A (PAPP\u2010A), in combination with maternal risk factors, mean arterial pressure (MAP) and uterine artery pulsatility index (UtA\u2010PI), after adjustment for the effect of aspirin in women receiving this treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Non\u2010intervention multicentre screening studies for PE in singleton pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Maternity hospitals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Two independent prospective studies of 8775 and 16\u2009451 women with singleton pregnancies attending for routine assessment at 11<jats:sup>+0<\/jats:sup>\u201313<jats:sup>+6<\/jats:sup> weeks' gestation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The competing risks model was used to estimate patient\u2010specific risks of delivery with PE at &lt;37\u00a0weeks' gestation based on maternal risk factors and combinations with MAP, UtA\u2010PI and either PlGF or PAPP\u2010A. McNemar's test was used to compare the detection rate (DR) of preterm\u2010PE of screening utilising PlGF versus PAPP\u2010A, after adjustments for the effects of aspirin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measure<\/jats:title><jats:p>Predictive performance for preterm\u2010PE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the combined data of 25\u2009226 women, including 678 (2.7%) who developed PE, there were 194(0.8%) with preterm\u2010PE. Addition of PlGF improved the DR of preterm\u2010PE, at 10% screen positive rate, by 18.4% (95% CI 12.2\u201324.6) in screening by maternal risk factors, by 19.9% (95% CI 13.6\u201326.2) in screening by maternal factors and MAP, and by 7.0% (95% CI 2.3\u201311.6) in screening by maternal factors, MAP and UtA\u2010PI. PAPP\u2010A did not significantly improve the DR provided by any combination of biomarkers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The predictive performance of first trimester PlGF for preterm\u2010PE is superior to that of PAPP\u2010A.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.17096","type":"journal-article","created":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T15:36:41Z","timestamp":1641915401000},"page":"1308-1317","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Serum PlGF compared with PAPP\u2010A in first trimester screening for preterm pre\u2010eclampsia: Adjusting for the effect of aspirin treatment"],"prefix":"10.1111","volume":"129","author":[{"given":"David","family":"Wright","sequence":"first","affiliation":[{"name":"Institute of Health Research University of Exeter  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Yi","family":"Tan","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"O'Gorman","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Argyro","family":"Syngelaki","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kypros H.","family":"Nicolaides","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1704559"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.11.561"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.11.1247"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.02.018"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.08.034"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17399"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.19039"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2018.11.1087"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.22093"},{"key":"e_1_2_10_11_1","unstructured":"RCOG.Small\u2010for\u2010Gestational\u2010Age Fetus Investigation and Management (Green\u2010top Guideline No. 31);2013. 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