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Outcomes were correlated to placental pathology in order to investigate the impact of virus\u2010related pathology on the villous capillary endothelium, trophoblast and other cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Maternal and fetal clinical outcomes and placental pathology in stillborn and live\u2010born infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Reduced fetal movements were reported (77%) and time from onset of maternal COVID\u201019 symptoms to signs of fetal distress among live\u2010born infants was 6 (3\u201312) days and to diagnosis of stillbirth 11 (2\u201325) days. Two of the live\u2010born infants died during the postnatal period. Signs of fetal distress led to emergency caesarean section in all live\u2010born infants with umbilical cord blood gases and low Apgar scores confirming intrauterine hypoxia. Five stillborn and one live\u2010born neonate had confirmed congenital transmission. Massive perivillous fibrinoid deposition, intervillositis and trophoblast necrosis were associated with SARS\u2010CoV\u20102 placental infection and congenital transmission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>SARS\u2010CoV\u20102 can cause rapid placental dysfunction with subsequent acute fetal hypoxia leading to intrauterine fetal compromise. Associated placental pathology included massive perivillous fibrinoid deposition, intervillositis and trophoblast degeneration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.17132","type":"journal-article","created":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T04:40:06Z","timestamp":1646368806000},"page":"1361-1374","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Clinical\u2010pathological features in placentas of pregnancies with <scp>SARS\u2010CoV<\/scp>\u20102 infection and adverse outcome: case series with and without congenital transmission"],"prefix":"10.1111","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0129-1578","authenticated-orcid":false,"given":"Mehreen","family":"Zaigham","sequence":"first","affiliation":[{"name":"Obstetrics &amp; Gynaecology, Institution of Clinical Sciences Lund Lund University  Lund Sweden"},{"name":"Department of Obstetrics and Gynaecology Sk\u00e5ne 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