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The following parameters were recorded at diagnosis: severe smallness (&lt;3rd centile); absent or reversed end\u2010diastolic velocity in umbilical artery; abnormal middle cerebral artery Doppler; abnormal cerebroplacental ratio; abnormal uterine artery Doppler; and absent or reversed end\u2010diastolic velocity in the ductus venosus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Logistic regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Predictive performance of EFW and Doppler parameters for short\u2010term adverse outcome of perinatal morbimortality and composite serious adverse outcomes (death, neurological impairment or severe bronchopulmonary dysplasia).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 155 pregnancies were included. There were 13 (8.4%) intrauterine and 11 (7.7%) neonatal deaths. A short\u2010term adverse perinatal outcome occurred in 40 (25.8%) pregnancies. There were 31 (20%) cases of serious adverse outcomes. For the prediction of serious adverse outcomes, the combination of absent or reversed end\u2010diastolic velocity in the umbilical artery and impaired middle cerebral artery detected by Doppler evaluation achieved a detection rate of 87%, with a false\u2010positive rate of 14% (accuracy 86%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In periviable isolated small\u2010for\u2010gestational\u2010age fetuses, a Doppler evaluation of the umbilical and fetal brain circulation can accurately predict short\u2010term adverse perinatal complications and serious adverse outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.17181","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T08:10:08Z","timestamp":1650355808000},"page":"485-493","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["<scp>Death and severe morbidity in isolated periviable small\u2010for\u2010gestational\u2010age fetuses<\/scp>"],"prefix":"10.1111","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5975-9834","authenticated-orcid":false,"given":"Eva","family":"Meler","sequence":"first","affiliation":[{"name":"Barcelona Centre for Maternal\u2013Fetal and Neonatal Medicine (Hospital Cl\u00ednic and Hospital Sant Joan de Deu), IDIBAPS (Institut D'Investigacions Biomediques August Pi i Sunyer), University of Barcelona, and Centre for Biomedical Research on Rare Diseases (CIBER\u2010ER)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edurne","family":"Mazarico","sequence":"additional","affiliation":[{"name":"Barcelona Centre for Maternal\u2013Fetal and Neonatal Medicine (Hospital Cl\u00ednic and Hospital Sant Joan de Deu), University of Barcelona and Institut de Recerca Sant Joan de D\u00e9u (IR\u2010SJD)  Barcelona Spain"},{"name":"Maternal and Child Health Development Network, RETICS (Redes Tem\u00e1ticas de 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