{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T16:16:44Z","timestamp":1780503404312,"version":"3.54.1"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T00:00:00Z","timestamp":1652227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the epidemiological changes in extended\u2010spectrum \u03b2\u2010lactamase\u2010producing Enterobacteriaceae (ESBL\u2010E) vaginal colonisation in pregnant women deemed at high risk, and to identify independent risk factors. Further, the differences in perinatal outcomes according to maternal ESBL\u2010E vaginal colonisation were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Cross\u2010sectional study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Republic of Korea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>A cohort of 1460 women admitted to our high\u2010risk pregnancy unit between 14<jats:sup>+0<\/jats:sup> and 36<jats:sup>+6<\/jats:sup>\u00a0weeks of gestation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The trend of changes in the association of ESBL\u2010E vaginal colonisation from January 2010 to December 2020 was analysed. The main outcomes were analysed over the study period and ESBL\u2010E vaginal colonisation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Rate of ESBL\u2010E vaginal colonisation, risk factors for ESBL\u2010E vaginal colonisation and perinatal outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The ESBL\u2010E vaginal colonisation rate has tended to increase over the past 11\u2009years, which was attributed to a significantly higher proportion of ESBL\u2010producing <jats:italic>Escherichia coli<\/jats:italic>. Cerclage (RR\u00a03.7, 95%\u00a0CI 2.19\u20136.40) and prior antibiotic treatment (RR\u00a04.0, 95%\u00a0CI 2.44\u20136.54) were found as independent risk factors for ESBL\u2010E vaginal colonisation. Earlier gestational age at delivery and higher proven early\u2010onset neonatal sepsis (EONS) rate were observed in the ESBL\u2010E\u2010positive group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The ESBL\u2010E vaginal colonisation rate in pregnant patients at high risk has increased over the past decade, and the independent risk factors for colonisation are cerclage and prior antibiotic treatment. Additionally, maternal ESBL\u2010E vaginal colonisation is associated with higher rates of proven EONS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.17194","type":"journal-article","created":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T11:24:53Z","timestamp":1650540293000},"page":"415-423","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Growing threat of <scp>extended\u2010spectrum \u03b2\u2010lactamase\u2010producing<\/scp>\u00a0<i>Enterobacteriaceae<\/i> colonisation in <scp>high\u2010risk<\/scp> pregnancies: A cross\u2010sectional study"],"prefix":"10.1111","volume":"130","author":[{"given":"Yun\u2010sun","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul South 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