{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:01:49Z","timestamp":1790805709018,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T00:00:00Z","timestamp":1655769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To examine the association between race and pre\u2010eclampsia and gestational hypertension after adjustment for factors in maternal characteristics and medical history in a screening study from the Fetal Medicine Foundation (FMF) in England, and to perform a systematic review and meta\u2010analysis of studies on pre\u2010eclampsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective observational study and systematic review with meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Two UK maternity hospitals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>A total of 168\u2009966 women with singleton pregnancies attending for routine ultrasound examination at 11\u201313 weeks of gestation without major abnormalities delivering at 24\u2009weeks or more of gestation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Regression analysis examined the association between race and pre\u2010eclampsia or gestational hypertension in the FMF data. Literature search to December 2021 was carried out to identify peer\u2010reviewed publications on race and pre\u2010eclampsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measure<\/jats:title><jats:p>Relative risk of pre\u2010eclampsia and gestational hypertension in women of black, South Asian and East Asian race by comparison to white women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In black women, the respective risks of total\u2010pre\u2010eclampsia and preterm\u2010pre\u2010eclampsia were 2\u2010fold and 2.5\u2010fold higher, respectively, and risk of gestational hypertension was 25% higher; in South Asian women there was a 1.5\u2010fold higher risk of preterm pre\u2010eclampsia but not of total\u2010pre\u2010eclampsia and in East Asian women there was no statistically significant difference in risk of hypertensive disorders. The literature search identified 19 studies that provided data on several million pregnancies, but 17 were at moderate or high\u2010risk of bias and only three provided risks adjusted for some maternal characteristics; consequently, these studies did not provide accurate contributions on different racial groups to the prediction of pre\u2010eclampsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In women of black and South Asian origin the risk of pre\u2010eclampsia, after adjustment for confounders, is higher than in white women.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.17240","type":"journal-article","created":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T07:27:40Z","timestamp":1653636460000},"page":"2082-2093","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Maternal race and pre\u2010eclampsia: Cohort study and systematic review with meta\u2010analysis"],"prefix":"10.1111","volume":"129","author":[{"given":"Anastasjja","family":"Arechvo","sequence":"first","affiliation":[{"name":"Harris Birthright Research Centre of Fetal Medicine King's College Hospital  London UK"},{"name":"Department of Obstetrics and Gynaecology, Institute of Clinical Sciences Lund Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Voicu","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre of Fetal Medicine King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9993-5249","authenticated-orcid":false,"given":"Mar\u00eda M.","family":"Gil","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre of Fetal Medicine King's College Hospital  London UK"},{"name":"Department of Obstetrics and Gynaecology, Hospital Universitario de Torrej\u00f3n, Torrej\u00f3n de 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