{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:26:38Z","timestamp":1747182398153,"version":"3.40.5"},"reference-count":53,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T00:00:00Z","timestamp":1657670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC_UU_00004\/01"],"award-info":[{"award-number":["MC_UU_00004\/01"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Ashkenazi\u2010Jewish (AJ) population\u2010based <jats:italic>BRCA<\/jats:italic> testing is acceptable, cost\u2010effective and amplifies primary prevention for breast &amp; ovarian cancer. However, data describing lifestyle impact are lacking. We report long\u2010term results of population\u2010based <jats:italic>BRCA<\/jats:italic> testing on lifestyle behaviour and cancer risk perception.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Two\u2010arm randomised controlled trials (ISRCTN73338115, GCaPPS): (a) population\u2010screening (PS); (b) family history (FH)\/clinical criteria testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>North London AJ\u2010population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population\/Sample<\/jats:title><jats:p>AJ women\/men &gt;18\u2009years. Exclusions: prior <jats:italic>BRCA<\/jats:italic> testing or first\u2010degree relatives of <jats:italic>BRCA<\/jats:italic>\u2010carriers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants were recruited through self\u2010referral. All participants received informed pre\u2010test genetic counselling. The intervention included genetic testing for three AJ <jats:italic>BRCA<\/jats:italic>\u2010mutations: 185delAG(c.68_69delAG), 5382insC(c.5266dupC) and 6174delT(c.5946delT). This was undertaken for all participants in the PS arm and participants fulfilling FH\/clinical criteria in the FH arm. Patients filled out customised\/validated questionnaires at baseline\/1\u2010year\/2\u2010year\/3\u2010year follow\u2010ups. Generalised linear\u2010mixed models adjusted for covariates and appropriate contrast tests were used for between\u2010group\/within\u2010group analysis of lifestyle and behavioural outcomes along with evaluating factors associated with these outcomes. Outcomes are adjusted for multiple testing (Bonferroni method), with <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.0039 considered significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Outcome measures<\/jats:title><jats:p>Lifestyle\/behavioural outcomes at baseline\/1\u2010year\/2\u2010year\/3\u2010year follow\u2010ups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>1034 participants were randomised to PS (<jats:italic>n<\/jats:italic>\u00a0=\u2009530) or FH (<jats:italic>n<\/jats:italic>\u00a0=\u2009504) arms. No significant difference was identified between PS\u2010 and FH\u2010based <jats:italic>BRCA<\/jats:italic> testing approaches in terms of dietary fruit\/vegetable\/meat consumption, vitamin intake, alcohol quantity\/ frequency, smoking behaviour (frequency\/cessation), physical activity\/exercise or routine breast mammogram screening behaviour, with outcomes not affected by <jats:italic>BRCA<\/jats:italic> test result. Cancer risk perception decreased with time following <jats:italic>BRCA<\/jats:italic> testing, with no difference between FH\/PS approaches, and the perception of risk was lowest in <jats:italic>BRCA<\/jats:italic>\u2010negative participants. Men consumed fewer fruits\/vegetables\/vitamins and more meat\/alcohol than women (<jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Population\u2010based and FH\u2010based AJ <jats:italic>BRCA<\/jats:italic> testing have similar long\u2010term lifestyle impacts on smoking, alcohol, dietary fruit\/vegetable\/meat\/vitamin, exercise, breast screening participation and reduced cancer risk perception.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.17253","type":"journal-article","created":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T07:14:27Z","timestamp":1656918867000},"page":"1970-1980","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Randomised trial of population\u2010based <scp><i>BRCA<\/i><\/scp> testing in Ashkenazi Jews: long\u2010term secondary lifestyle behavioural outcomes"],"prefix":"10.1111","volume":"129","author":[{"given":"Matthew","family":"Burnell","sequence":"first","affiliation":[{"name":"MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology University College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4081-6883","authenticated-orcid":false,"given":"Faiza","family":"Gaba","sequence":"additional","affiliation":[{"name":"Wolfson Institute of Population Health, Barts CRUK Cancer Centre Queen Mary University of London  London UK"},{"name":"Department of Gynaecological Oncology Barts Health NH Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Sobocan","sequence":"additional","affiliation":[{"name":"Wolfson Institute of Population Health, Barts CRUK Cancer Centre Queen Mary University of London  London UK"},{"name":"Department of Gynaecological Oncology Barts Health NH Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakshit","family":"Desai","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Oncology Barts Health NH Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saskia","family":"Sanderson","sequence":"additional","affiliation":[{"name":"Behavioural Sciences Unit Department Epidemiology and Public Health University College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly","family":"Loggenberg","sequence":"additional","affiliation":[{"name":"Department Clinical Genetics North East Thames Regional Genetics Unit Great Ormond Street Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sue","family":"Gessler","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Oncology Institute for Women's Health University College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucy","family":"Side","sequence":"additional","affiliation":[{"name":"University Hospital Southampton NHS Foundation Trust  Southampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela F.","family":"Brady","sequence":"additional","affiliation":[{"name":"Department Clinical Genetics North West Thames Regional Genetics Unit Northwick Park Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huw","family":"Dorkins","sequence":"additional","affiliation":[{"name":"St Peter's College University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvonne","family":"Wallis","sequence":"additional","affiliation":[{"name":"West Midlands Regional Genetics Laboratory Birmingham Women's NHS Foundation Trust  Birmingham UK"},{"name":"Depatment Clinical Genetics West Midlands Regional Genetics Service Birmingham Women's NHS Foundation Trust  Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Depatment Clinical Genetics Guy's Hospital  London UK"},{"name":"University of Technology Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Legood","sequence":"additional","affiliation":[{"name":"Department of Health Services Research and Policy London School of Hygiene &amp; 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