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Single\u2010nucleotide polymorphism array detected CNVs of at least 500\u2009kb. CNVs were classified into two groups: normal, defined as no CNV &gt;500\u2009kb or benign CNVs, and abnormal, defined as pathogenic or variants of unknown clinical significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>The proportions of abnormal CNVs and normal CNVs compared between stillbirth cases with and without PPLs using the Wald Chi\u2010square test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 387 stillborn fetuses, 327 (84.5%) had maternal vascular PPLs and 60 (15.6%) had abnormal CNVs. Maternal vascular PPLs were more common in stillborn fetuses with abnormal CNVs than in those with normal CNVs (81.7% versus 64.2%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.008). The proportions of fetal vascular, maternal\/fetal inflammatory and immune\/idiopathic PPLs were similar among stillborn fetuses with abnormal CNVs and those with normal CNVs. Pathogenic CNVs in stillborn fetuses with maternal vascular PPLs spanned several known genes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Abnormal placental\/fetal CNVs were associated with maternal vascular PPLs in stillbirth cases. The findings may provide insight into the mechanisms of specific genetic abnormalities associated with placental dysfunction and stillbirth.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.17269","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T14:34:09Z","timestamp":1658759649000},"page":"2125-2131","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Copy number variants and placental abnormalities in stillborn fetuses: A secondary analysis of the Stillbirth Collaborative Research Network study"],"prefix":"10.1111","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4571-9740","authenticated-orcid":false,"given":"Tsegaselassie","family":"Workalemahu","sequence":"first","affiliation":[{"name":"University of Utah Health  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Dalton","sequence":"additional","affiliation":[{"name":"University of Utah Health  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Allshouse","sequence":"additional","affiliation":[{"name":"University of Utah Health  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew Z.","family":"Carey","sequence":"additional","affiliation":[{"name":"University of Utah Health  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica M.","family":"Page","sequence":"additional","affiliation":[{"name":"University of Utah Health  Salt Lake City Utah USA"},{"name":"Intermountain Healthcare  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan R.","family":"Blue","sequence":"additional","affiliation":[{"name":"University of Utah Health  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Thorsten","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center  New York New York USA"},{"name":"RTI International  Research Triangle Park North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert L.","family":"Goldenberg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Columbia University  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halit","family":"Pinar","sequence":"additional","affiliation":[{"name":"Division of Perinatal Pathology Brown University School of Medicine  Providence Rhode Island USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uma M.","family":"Reddy","sequence":"additional","affiliation":[{"name":"Obstetrics, Gynecology &amp; 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