{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:33:16Z","timestamp":1789759996033,"version":"4.0.1"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:00:00Z","timestamp":1661299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the incidences of early and late\u2010onset neonatal sepsis, including group B streptococcus (GBS) and <jats:italic>Escherichia coli<\/jats:italic> (<jats:italic>E.\u00a0coli<\/jats:italic>) before and after implementation of universal screening and intrapartum antibiotics prophylaxis (IAP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Eight public hospitals and 31 Maternal and Child Health Centres (in Hong Kong.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>460\u2009552 women attending routine antenatal service from 2009 to 2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Universal culture\u2010based GBS screening has been offered to eligible women since 2012. Total births, GBS screening tests, maternal GBS colonisation and neonatal sepsis with positive blood or cerebrospinal fluid were retrieved from clinical and laboratory database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Maternal GBS colonisation rate, early\u2010 and late\u2010onset neonatal sepsis (including GBS and <jats:italic>E.\u00a0coli<\/jats:italic>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 318\u2009740 women with universal culture\u2010based screening, 63\u2009767 women (20.0%) screened positive. After implementation of GBS screening and IAP, the incidence of early\u2010onset neonatal sepsis decreased (3.25 versus 2.26 per 1000 live births, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), including those caused by GBS (1.03 versus 0.26 per 1000 live births, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Segmented regression showed that change in early\u2010onse GBS sepsis incidence after screening was the only significant variable in the outcome trend. There was no significant evidence of increase in incidence of late\u2010onset neonatal sepsis including those caused by GBS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Universal culture\u2010based GBS screening and IAP were associated with reduction in early\u2010onset neonatal sepsis including GBS disease. Although an increase in incidence of late\u2010onset neonatal sepsis including those caused by GBS cannot be totally ruled out, we did not identify significant evidence that this occurred.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.17279","type":"journal-article","created":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T05:40:05Z","timestamp":1660196405000},"page":"24-31","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Incidence of neonatal sepsis after universal antenatal culture\u2010based screening of group B streptococcus and intrapartum antibiotics: A multicentre retrospective cohort study"],"prefix":"10.1111","volume":"130","author":[{"given":"Ying Tze Viola","family":"Chan","sequence":"first","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology Kwong Wah Hospital  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven Yuk Fai","family":"Lau","sequence":"additional","affiliation":[{"name":"Clinical Research Centre Kwong Wah Hospital  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuk Yi Annie","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology Prince of Wales Hospital  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology Queen Elizabeth Hospital  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choi Wah","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology United Christian Hospital  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee Ting","family":"Kwong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology Tuen Mun Hospital  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology Queen Mary Hospital  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology Pamela Youde Nethersole Eastern Hospital  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sau Lan","family":"Mok","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology Princess Margaret Hospital  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinci","family":"Ma","sequence":"additional","affiliation":[{"name":"Family Health Service Department of Health  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yim Chong","family":"Lo","sequence":"additional","affiliation":[{"name":"Family Health Service Department of Health  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwok Yin","family":"Leung","sequence":"additional","affiliation":[{"name":"Private Practice  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wing Cheong","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology Kwong Wah Hospital  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"HA\u2010DH Liaison Committee, COC (O&G)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix658"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2005.029058"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1984.tb04759.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix656"},{"issue":"6","key":"e_1_2_11_6_1","first-page":"CD007467","article-title":"Intrapartum antibiotics for known maternal Group B streptococcal colonization","author":"Ohlsson A","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_11_7_1","unstructured":"Active Bacterial Core Surveillance (ABCs) 2012 GBS Report | CDC [Internet]. 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