{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:51:55Z","timestamp":1792522315367,"version":"4.5.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T00:00:00Z","timestamp":1662940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To measure condition\u2010specific detection rates for 14 physical conditions screened for by the NHS fetal anomaly screening programme (FASP) fetal anomaly (FA) ultrasound scan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective audit of 12\u2009694 diagnoses across a 3\u2010year national cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>All English NHS and crown\u2010dependency hospital trusts providing maternity services.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Pregnancies booked for maternity services with an expected date of delivery between 1 April 2017 and 31 March 2020 and at least one diagnosis of a condition screened for by FASP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Active multi\u2010source ascertainment, linkage, audit and validation of clinical information to identify the subset of diagnoses meeting the condition\u2010specific positivity threshold for the FA scan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measure<\/jats:title><jats:p>The accuracy of the FA scan compared with diagnostic reference standards.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>FA scan detection rates were: anencephaly 96.3% (95% confidence interval [CI] 81.7\u201399.3%), atrioventricular septal defect: 69.2% (95% CI 65.8\u201372.4%), bilateral renal agenesis: 98.7% (95% CI 95.4\u201399.6%), cleft lip: 89.5% (95% CI 87.8\u201390.9%), congenital diaphragmatic hernia: 60.8% (95% CI 56.5\u201365%), Edwards syndrome: 73.8% (95% CI 67.5\u201379.3%), exomphalos: 59.4% (95% CI 49.4\u201368.7%), gastroschisis: 88.6% (95% CI 79\u201394.1%), hypoplastic left heart syndrome: 92.7% (95% CI 90\u201394.8%), lethal skeletal dysplasia: 93.2% (95% CI 88.6\u201396%), Patau syndrome: 82.3% (95% CI 72.4\u201389.1%), spina bifida: 93.8% (95% CI 91.8\u201395.3%), tetralogy of Fallot: 75.4% (95% CI 72.1\u201378.4%) and transposition of the great arteries: 84.9% (95% CI 81.7\u201387.5%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The performance of the FA scan is above the expectations set in 2010 for most conditions. For the remaining conditions, the majority of fetuses and babies affected are detected before the FA scan.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.17287","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T07:09:28Z","timestamp":1661756968000},"page":"51-58","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Detection rates of a national fetal anomaly screening programme: A national cohort study"],"prefix":"10.1111","volume":"130","author":[{"given":"Nicholas","family":"Aldridge","sequence":"first","affiliation":[{"name":"National Congenital Anomaly and Rare Disease Registration Service, NHS Digital  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranav","family":"Pandya","sequence":"additional","affiliation":[{"name":"University College London Hospitals NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Rankin","sequence":"additional","affiliation":[{"name":"Population Health Sciences Institute, Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Miller","sequence":"additional","affiliation":[{"name":"National Congenital Anomaly and Rare Disease Registration Service, NHS Digital  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Broughan","sequence":"additional","affiliation":[{"name":"National Congenital Anomaly and Rare Disease Registration Service, NHS Digital  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Permalloo","sequence":"additional","affiliation":[{"name":"Screening Quality Assurance Service, NHS England and NHS Improvement  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"McHugh","sequence":"additional","affiliation":[{"name":"NHS Fetal Anomaly Screening Programme, NHS England and NHS Improvement  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Stevens","sequence":"additional","affiliation":[{"name":"National Congenital Anomaly and Rare Disease Registration Service, NHS Digital  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2016-311845"},{"key":"e_1_2_11_3_1","unstructured":"KirwanD The NHS Fetal Anomaly Screening Programme.18+0to 20+6weeks fetal anomaly scan National Standards and guidance for England. 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Available from:https:\/\/www.gov.uk\/government\/publications\/evidence\u2010review\u2010criteria\u2010national\u2010screening\u2010programmes\/criteria\u2010for\u2010appraising\u2010the\u2010viability\u2010effectiveness\u2010and\u2010appropriateness\u2010of\u2010a\u2010screening\u2010programme"},{"key":"e_1_2_11_9_1","unstructured":"UK National Screening Committee.Guidance for the development production and review of information to support UK population screening programmes. Public Health England 2018:4."},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38300.665301.3A"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2017-312833"},{"key":"e_1_2_11_12_1","unstructured":"NHS fetal anomaly screening programme 20\u2010week scan base menu [Internet]. Public Health England; c2021 [cited 2020 Feb 21]. 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Available from:https:\/\/www.gov.uk\/government\/publications\/fetal\u2010anomaly\u2010screening\u2010laboratory\u2010handbook\u2010downs\u2010edwards\u2010and\u2010pataus\u2010syndromes\/fetal\u2010anomaly\u2010screening\u2010laboratory\u2010handbook#screening\u2010tests"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1927.10502953"},{"key":"e_1_2_11_16_1","unstructured":"PHE screening blog [Internet]. Public Health England; c2021 [cited 2020 Feb 21]. Have your say on proposed changes to the NHS FASP standards. Available from:https:\/\/phescreening.blog.gov.uk\/2021\/02\/22\/fasp\u2010standards\u2010consultation\/"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.15589"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta4160"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.16468"},{"key":"e_1_2_11_20_1","unstructured":"Journals Library [Internet]. 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