{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T06:57:39Z","timestamp":1789023459689,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:00:00Z","timestamp":1663113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015675","name":"National Blood Authority","doi-asserted-by":"publisher","award":["117"],"award-info":[{"award-number":["117"]}],"id":[{"id":"10.13039\/100015675","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001786","name":"University of Adelaide","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001786","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To test the equivalence of two doses of intravenous iron (ferric carboxymaltose) in pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Parallel, two\u2010arm equivalence randomised controlled trial with an equivalence margin of 5%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Single centre in Australia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>278 pregnant women with iron deficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants received either 500 mg (<jats:italic>n<\/jats:italic>\u00a0=\u00a0152) or 1000\u2009mg (<jats:italic>n<\/jats:italic>\u00a0=\u00a0126) of intravenous ferric carboxymaltose in the second or third trimester.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>The proportion of participants requiring additional intravenous iron (500\u2009mg) to achieve and maintain ferritin &gt;30\u2009microg\/L (diagnostic threshold for iron deficiency) at 4\u2009weeks post\u2010infusion, and at 6\u2009weeks, and 3\u2010, 6\u2010 and 12\u2010months postpartum. Secondary endpoints included repeat infusion rate, iron status, birth and safety outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The two doses were not equivalent within a 5% margin at any time point. At 4\u2009weeks post infusion, 26\/73 (36%) participants required a repeat infusion in the 500\u2010mg group compared with 5\/67 (8%) in the 1000\u2010mg group: difference in proportions, 0.283 (95% confidence interval [CI] 0.177\u20130.389). Overall, participants in the 500\u2010mg arm received twice the repeat infusion rate (0.81 [SD\u00a0=\u00a00.824] versus 0.40 [SD\u00a0=\u00a00.69], rate ratio 2.05, 95% CI 1.45\u20132.91).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Administration of 1000 mg ferric carboxymaltose in pregnancy maintains iron stores and reduces the need for repeat infusions. A 500\u2010 mg dose requires ongoing monitoring to ensure adequate iron stores are reached and sustained.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.17288","type":"journal-article","created":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T10:59:28Z","timestamp":1662029968000},"page":"15-23","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Testing equivalence of two doses of intravenous iron to treat iron deficiency in pregnancy: A randomised controlled trial"],"prefix":"10.1111","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3755-8609","authenticated-orcid":false,"given":"Bernd","family":"Froessler","sequence":"first","affiliation":[{"name":"Department of Anaesthesia, Northern Adelaide Local Health Network Lyell McEwin Hospital  Elizabeth Vale South Australia Australia"},{"name":"Discipline of Acute Care Medicine, Adelaide Medical School The University of Adelaide  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus Oliver","family":"Schubert","sequence":"additional","affiliation":[{"name":"Discipline of Psychiatry, Adelaide Medical School The University of Adelaide  Adelaide South Australia Australia"},{"name":"Northern Adelaide Mental Health Services Lyell McEwin Hospital  Elizabeth Vale South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Palm","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Northern Adelaide Local Health Network Lyell McEwin Hospital  Elizabeth Vale South Australia Australia"},{"name":"Discipline of Acute Care Medicine, Adelaide Medical School The University of Adelaide  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Church","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Northern Adelaide Local Health Network Lyell McEwin Hospital  Elizabeth Vale South Australia Australia"},{"name":"Discipline of Acute Care Medicine, Adelaide Medical School The University of Adelaide  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Aboustate","sequence":"additional","affiliation":[{"name":"Robinson Research Institute  North Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thu\u2010Lan","family":"Kelly","sequence":"additional","affiliation":[{"name":"Quality Use of Medicines Pharmacy Research Centre University of South Australia, Clinical and Health Sciences  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gus A.","family":"Dekker","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Lyell McEwin Hospital  Elizabeth Vale South Australia Australia"},{"name":"Adelaide Medical School The University of Adelaide  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolette A.","family":"Hodyl","sequence":"additional","affiliation":[{"name":"Adelaide Medical School The University of Adelaide  Adelaide South Australia Australia"},{"name":"Hunter Medical Research Institute  Newcastle New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2015.11.002"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32154-2"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-05-815944"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.03.006"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2017.1394833"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogc.2017.09.027"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13252"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(18)30078-0"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14961"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60696-6"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0225123"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.12.011"},{"key":"e_1_2_10_14_1","unstructured":"WHO.World Health Organization. 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