{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:34:58Z","timestamp":1787726098896,"version":"build-2784847793"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,10,9]],"date-time":"2022-10-09T00:00:00Z","timestamp":1665273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To retrospectively describe a large series of pregnancies in women with hereditary haemorrhagic telangiectasia followed in our reference centre, plus neonatal outcomes, to better understand the risks of complications and to improve their prevention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A retrospective descriptive study conducted through a phone questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Reference centre for hereditary haemorrhagic telangiectasia in Lyon, France.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Women meeting the following criteria: (1) alive and aged \u226518\u2009years; (2) with a definite clinical and\/or genetic diagnosis of hereditary haemorrhagic telangiectasia; and (3) with at least one full\u2010term pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Maternal and perinatal outcomes of pregnancies in women with hereditary haemorrhagic telangiectasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five hundred and sixty\u2010two pregnancies were reported in 207 women with hereditary haemorrhagic telangiectasia. A total of 271 complications (48.2%) were registered. Of these, 149 (55%) non\u2010specific complications, 110 (40.6%) non\u2010severe specific complications and 12 (4.4%) severe specific complications were registered. There were four cases of haemoptysis and two cases of transient ischaemic attack related to pulmonary arteriovenous malformations. Four patients had severe decompensated dyspnoea, related to pulmonary arteriovenous malformations in three cases and to pulmonary arteriovenous malformations associated with severe hepatic arteriovenous malformations in one case. Hepatobiliary necrosis occurred in one case. Epidural or spinal anaesthesia was performed in 139 of 452 deliveries (31%), without complications. There were 12 reports of congenital anomalies in 461 live births (3%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Most pregnancies in hereditary haemorrhagic telangiectasia women are uneventful; complications are rare but can be severe. Women thus need to be educated about screening and possible pregnancy\u2010related risks before becoming pregnant.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.17303","type":"journal-article","created":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T13:15:56Z","timestamp":1664198156000},"page":"303-311","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Obstetrical and neonatal complications in hereditary haemorrhagic telangiectasia: A retrospective study"],"prefix":"10.1111","volume":"130","author":[{"given":"Laura","family":"Delagrange","sequence":"first","affiliation":[{"name":"Hospices Civils de Lyon, Centre de r\u00e9f\u00e9rence pour la maladie de Rendu\u2013Osler H\u00f4pital Femme\u2010M\u00e8re\u2010Enfant  Bron France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8257-7625","authenticated-orcid":false,"given":"Olivier","family":"Dupuis","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon, Service de Gyn\u00e9cologie\u2013Obst\u00e9trique H\u00f4pital Lyon\u2010Sud  Pierre\u2010B\u00e9nite France"},{"name":"Facult\u00e9 de M\u00e9decine Universit\u00e9 de Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3085-9580","authenticated-orcid":false,"given":"Anne\u2010Emmanuelle","family":"Fargeton","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon, Centre de r\u00e9f\u00e9rence pour la maladie de Rendu\u2013Osler H\u00f4pital Femme\u2010M\u00e8re\u2010Enfant  Bron France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine","family":"Bernard","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon, P\u00f4le de Sant\u00e9 Publique  Lyon France"},{"name":"Universit\u00e9 Lyon\u20091  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2412-4767","authenticated-orcid":false,"given":"Evelyne","family":"Decullier","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon, P\u00f4le de Sant\u00e9 Publique  Lyon France"},{"name":"Universit\u00e9 Lyon\u20091  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8834-5526","authenticated-orcid":false,"given":"Sophie","family":"Dupuis\u2010Girod","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon, Centre de r\u00e9f\u00e9rence pour la maladie de Rendu\u2013Osler H\u00f4pital Femme\u2010M\u00e8re\u2010Enfant  Bron France"},{"name":"Universit\u00e9 Grenoble Alpes, INSERM, CEA BIG\u2010Biologie du Cancer et de l'Infection  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,9]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(20000306)91:1<66::AID-AJMG12>3.0.CO;2-P"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-018-0850-2"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1294-345"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0696-189"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15732-2"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2008.01786.x"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2015-308476"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)36252-5"},{"issue":"12","key":"e_1_2_13_10_1","first-page":"879","article-title":"Medical complications of pregnancy in hereditary haemorrhagic telangiectasia","volume":"88","author":"Shovlin CL","year":"1995","journal-title":"Qjm"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35458"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000120"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgyn.2012.04.014"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgyn.2014.09.020"},{"key":"e_1_2_13_15_1","unstructured":"EURO\u2010PERISTAT Project with SCPE and EUROCAT. 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