{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:42:05Z","timestamp":1791996125215,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:00:00Z","timestamp":1666310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["311862\/2020\u20109"],"award-info":[{"award-number":["311862\/2020\u20109"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E\u201026\/201.166\/2022"],"award-info":[{"award-number":["E\u201026\/201.166\/2022"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess whether the incidence and aggressiveness of molar pregnancy (MP) and postmolar gestational trophoblastic neoplasia (GTN) changed during the COVID\u201019 pandemic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Observational study with two separate designs: retrospective multicentre cohort of patients with MP\/postmolar GTN and a cross\u2010sectional analysis, with application of a questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Six Brazilian Reference Centres on gestational trophoblastic disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>2662 patients with MP\/postmolar GTN treated from March\u2013December\/2015\u20132020 were retrospectively evaluated and 528 of these patients answered a questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Longitudinal retrospective multicentre study of patients diagnosed with MP\/ postmolar GTN at presentation and a cross\u2010sectional analysis, with application of a questionnaire, exclusive to patients treated during the period of study, to assess living and health conditions during the COVID\u201019 pandemic compared with previous years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>The incidence of MP\/postmolar GTN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with the last 5 pre\u2010pandemic years, MP\/postmolar GTN incidence remained stable during 2020 (COVID\u201019 pandemic). Multivariable logistic regression, adjusted for the patient age, showed that during 2020, presentation with MP was more likely to be &gt;10\u2009weeks of gestation (adjusted odds ratio [aOR] 2.50, 95% confidence interval [CI] 1.90\u20133.29, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), have a pre\u2010evacuation hCG level\u2009\u2265100\u2009000\u2009iu\/l (aOR 1.77, 95% CI 1.38\u20132.28, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and time to the initiation of chemotherapy \u22657\u00a0months (aOR 1.86, 95% CI 1.01\u20133.43, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.047) when compared with 2015\u20132019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although the incidence of MP\/postmolar GTN remained stable during the COVID\u201019 pandemic in Brazil, the pandemic was associated with greater gestational age at MP diagnosis and more protracted delays in initiation of chemotherapy for postmolar GTN.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.17313","type":"journal-article","created":{"date-parts":[[2022,10,9]],"date-time":"2022-10-09T12:38:41Z","timestamp":1665319121000},"page":"292-302","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Influence of COVID\u201019 pandemic on molar pregnancy and\u00a0postmolar gestational trophoblastic neoplasia: An observational study"],"prefix":"10.1111","volume":"130","author":[{"given":"Vanessa","family":"Campos","sequence":"first","affiliation":[{"name":"Department of Maternal Child, Postgraduate Program in Medical Sciences Fluminense Federal University  Niter\u00f3i Brazil"},{"name":"Department of Obstetrics and Gynaecology, Postgraduate Program in Perinatal Health, Faculty of Medicine Maternity School of Rio de Janeiro Federal University  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Paiva","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Postgraduate Program in Perinatal Health, Faculty of Medicine Maternity School of Rio de Janeiro Federal University  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilian","family":"Padron","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Postgraduate Program in Perinatal Health, Faculty of Medicine Maternity School of Rio de Janeiro Federal University  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Freitas","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Postgraduate Program in Perinatal Health, Faculty of Medicine Maternity School of Rio de Janeiro Federal University  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana Giongo","family":"Pedrotti","sequence":"additional","affiliation":[{"name":"Hospital Moinhos de Vento  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue Yazaki","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Paulista School of Medicine S\u00e3o Paulo Federal University  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maur\u00edcio","family":"Viggiano","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Goiania Trophoblastic Disease Center (Clinics Hospital of Goias Federal University)  Goiania Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Division of Recife Trophoblastic Disease Center (Clinics Hospital of Pernambuco Federal University)  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Rohr","sequence":"additional","affiliation":[{"name":"Division of Recife Trophoblastic Disease Center (Clinics Hospital of Pernambuco Federal University)  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Mauro","family":"Madi","sequence":"additional","affiliation":[{"name":"Division of Caxias do Sul Trophoblastic Disease Center General Hospital of Caxias do Sul, School of Medicine, Center for Biological and Health Sciences, Caxias do Sul University  Caxias do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago Pedrom\u00f4nico","family":"Arrym","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Sao Paulo Medical School  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Postgraduate Program in Perinatal Health, Faculty of Medicine Maternity School of Rio de Janeiro Federal University  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula Vieira","family":"dos Santos Esteves","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Postgraduate Program in Perinatal Health, Faculty of Medicine Maternity School of Rio de Janeiro Federal University  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joffre Amim","family":"Junior","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Postgraduate Program in Perinatal Health, Faculty of Medicine Maternity School of Rio de Janeiro Federal University  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge Rezende","family":"Filho","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Postgraduate Program in Perinatal Health, Faculty of Medicine Maternity School of Rio de Janeiro Federal University  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin M.","family":"Elias","sequence":"additional","affiliation":[{"name":"New England Trophoblastic Disease Center, Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology Brigham and Women's Hospital, Dana Farber Cancer Institute, Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil\u00a0S.","family":"Horowitz","sequence":"additional","affiliation":[{"name":"New England Trophoblastic Disease Center, Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology Brigham and Women's Hospital, Dana Farber Cancer Institute, Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2942-6182","authenticated-orcid":false,"given":"Ant\u00f4nio","family":"Braga","sequence":"additional","affiliation":[{"name":"Department of Maternal Child, Postgraduate Program in Medical Sciences Fluminense Federal University  Niter\u00f3i Brazil"},{"name":"Department of Obstetrics and Gynaecology, Postgraduate Program in Perinatal Health, Faculty of Medicine Maternity School of Rio de Janeiro Federal University  Rio de Janeiro Brazil"},{"name":"Postgraduate Program in Applied Health Sciences Vassouras University  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross S.","family":"Berkowitz","sequence":"additional","affiliation":[{"name":"New England Trophoblastic Disease Center, Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology Brigham and Women's Hospital, Dana Farber Cancer Institute, Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2019.7364"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0000000000000674"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.5306\/wjco.v10.i2.28"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2015.05.002"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000000682"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2020.04.704"},{"key":"e_1_2_10_8_1","first-page":"210","article-title":"Maternal near miss according to World Health Organization classification among women with a hydatidiform mole: experience at the New England trophoblastic disease center, 1994\u20102013","volume":"61","author":"Sun SY","year":"2016","journal-title":"J Reprod Med"},{"key":"e_1_2_10_9_1","first-page":"305","article-title":"Influence of hydatidiform mole follow\u2010up setting on postmolar gestational trophoblastic neoplasia outcomes: a cohort study","volume":"57","author":"Dantas PR","year":"2012","journal-title":"J Reprod Med"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.05.042"},{"key":"e_1_2_10_11_1","volume-title":"Brazilian confirmed cases","author":"Coronavirus Panel","year":"2021"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.13310"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2021.02.035"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(78)90829-3"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.06.073"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2020\/e1724"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(02)00063-2"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002522"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.13617"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2016.09.012"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12615"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1590\/SO100-720320150005366"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt345"},{"key":"e_1_2_10_24_1","first-page":"1723","article-title":"Updated diagnostic criteria for partial and complete hydatidiform moles in early pregnancy","volume":"23","author":"Sebire NJ","year":"2003","journal-title":"Anticancer Res"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.15289"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-5573-8-1"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1688566"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(95)00268-V"},{"key":"e_1_2_10_29_1","first-page":"11","article-title":"Complete molar pregnancy. Clinical trends at king Fahad hospital, Riyad, Kingdom of Saudi Arabia","volume":"43","author":"Felemban AA","year":"1998","journal-title":"J Reprod Med"},{"key":"e_1_2_10_30_1","first-page":"21","article-title":"Complete hydatidiform mole, comparison of clinicopathologic features, current and past","volume":"43","author":"Mosher R","year":"1998","journal-title":"J Reprod Med"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deg008"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181945a4f"},{"key":"e_1_2_10_33_1","first-page":"151","article-title":"Reduction of postmolar gestational trophoblastic neoplasia by early diagnosis and treatment","volume":"54","author":"Ben\u2010Arie A","year":"2009","journal-title":"J Reprod Med"},{"key":"e_1_2_10_34_1","first-page":"470","article-title":"Complete hydatidiform mole. Change in clinical profile over three decades","volume":"57","author":"Lertkhachonsuk A","year":"2012","journal-title":"J Reprod Med"},{"key":"e_1_2_10_35_1","first-page":"51","article-title":"Current clinical features of complete and partial hydatidiform mole in Sweden","volume":"59","author":"Joneborg U","year":"2014","journal-title":"J Reprod Med"},{"key":"e_1_2_10_36_1","first-page":"241","article-title":"Epidemiological report on the treatment of patients with gestational trophoblastic disease in 10 Brazilian referral centers results after 12\u2009years since international FIGO 2000 consensus","volume":"59","author":"Braga A","year":"2014","journal-title":"J Reprod Med"},{"key":"e_1_2_10_37_1","first-page":"235","article-title":"Hydatidiform mole and its complications: review of patient profiles and management at the University of The Philippines\u2010Philippine general hospital","volume":"59","author":"Cagayan M","year":"2014","journal-title":"J Reprod Med"},{"key":"e_1_2_10_38_1","first-page":"224","article-title":"Centralized coordination of decentralized assistance for patients with gestational trophoblastic disease in Brazil: a viable strategy for developing countries","volume":"61","author":"Braga A","year":"2016","journal-title":"J Reprod Med"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.17313","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1471-0528.17313","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.17313","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T00:16:33Z","timestamp":1692490593000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/1471-0528.17313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,21]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1111\/1471-0528.17313"],"URL":"https:\/\/doi.org\/10.1111\/1471-0528.17313","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,21]]},"assertion":[{"value":"2022-06-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}