{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:02:00Z","timestamp":1793070120921,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T00:00:00Z","timestamp":1669248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To elaborate the associations of different cycle regimens (natural cycle [NC], stimulated cycle [SC], hormone replacement cycle [HRC]) on maternal and neonatal adverse pregnancy outcomes after frozen\u2013thawed embryo transfers (FET).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Population\u2010based registry study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Swiss IVF Registry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population or Sample<\/jats:title><jats:p>Singleton (<jats:italic>n<\/jats:italic>\u00a0=\u20094636) and twin (<jats:italic>n<\/jats:italic>\u00a0=\u2009544) live births after NC\u2010FET (<jats:italic>n<\/jats:italic>\u00a0=\u2009776), SC\u2010FET (<jats:italic>n<\/jats:italic>\u00a0=\u2009758) or HRC\u2010FET (<jats:italic>n<\/jats:italic>\u00a0=\u20093646) registered from 2014 to 2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifteen pregnancy pathologies were modelled for singleton and twin pregnancies using mixed models adjusted for cycle regimen, delivery, fertilisation technique, chronic anovulation, age of mother and centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Maternal (vaginal bleeding, isolated arterial hypertension and pre\u2010eclampsia) and neonatal (gestational age, birthweight, mode of delivery) adverse pregnancy outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In singleton pregnancies, the incidences of bleeding in first trimester, isolated hypertension and pre\u2010eclampsia were highest in HRC\u2010FET with doubled odds of bleeding in first trimester (adjusted odds ratio [aOR] 2.23; 95% CI 1.33\u20133.75), isolated hypertension (aOR 2.50; 95% CI 1.02\u20136.12) and pre\u2010eclampsia (aOR 2.16; 95% CI 1.13\u20134.12) in HRC\u2010FET vs. NC\u2010FET and with doubled respectively sixfold odds of bleeding (aOR 2.08; 95% CI 1.03\u20134.21) and pre\u2010eclampsia (6.02; 95% CI 1.38\u201326.24) in HRC\u2010FET versus SC\u2010FET. In twin pregnancies, the incidence of pre\u2010eclampsia was highest in HRC\u2010FET with numerically higher odds of pre\u2010eclampsia in HRC\u2010FET versus NC\u2010FET and versus SC\u2010FET.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data implied the highest maternal risks of hypertensive disorders in HRC\u2010FET, therefore clinicians should prefer SC\u2010FET or NC\u2010FET if medically possible.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.17343","type":"journal-article","created":{"date-parts":[[2022,11,13]],"date-time":"2022-11-13T11:39:00Z","timestamp":1668339540000},"page":"377-386","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Hormone replacement cycles are associated with a higher risk of hypertensive disorders: Retrospective cohort study in singleton and twin pregnancies"],"prefix":"10.1111","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7858-2288","authenticated-orcid":false,"given":"Janna","family":"Pape","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Reproductive Medicine, Inselspital University Women's Hospital  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00e9my","family":"Levy","sequence":"additional","affiliation":[{"name":"FIVNAT Statistician, Swiss Society for Reproductive Medicine  Aarau Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"von Wolff","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Reproductive Medicine, Inselspital University Women's Hospital  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,24]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoz004"},{"issue":"2","key":"e_1_2_12_3_1","article-title":"Fresh versus frozen embryo transfers in assisted reproduction","volume":"2","author":"Zaat T","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.11.2459"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hox012"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoab026"},{"issue":"7","key":"e_1_2_12_7_1","article-title":"Cycle regimens for frozen\u2010thawed embryo transfer","volume":"7","author":"Ghobara T","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex285"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.03.010"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dez079"},{"key":"e_1_2_12_11_1","doi-asserted-by":"crossref","unstructured":"WangB ZhuQ WangY.Pregnancy outcomes after different cycle regimens for frozen\u2010thawed embryo transfer: a retrospective study using propensity score matching.2020;7(327).","DOI":"10.3389\/fmed.2020.00327"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-017-0869-7"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-021-06014-w"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-020-00601-3"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00239.2012"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.12046"},{"issue":"7","key":"e_1_2_12_17_1","first-page":"647","article-title":"Pregnancy hormones, pre\u2010eclampsia, and implications for breast cancer risk in the offspring","volume":"12","author":"Tamimi R","year":"2003","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2011.11.010"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0116"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.12043"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719118776792"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-019-01420-1"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2020.03.009"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2020.10.039"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2021.01.015"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.1219"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmx031"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/det272"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.00104"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.115.129114"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-011-0244-5"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00070-7"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.23736\/S0026-4784.18.04230-2"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.03.033"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmab027"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-021-05637-3"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.17343","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1471-0528.17343","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.17343","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T03:19:52Z","timestamp":1692415192000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/1471-0528.17343"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,24]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1111\/1471-0528.17343"],"URL":"https:\/\/doi.org\/10.1111\/1471-0528.17343","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,24]]},"assertion":[{"value":"2022-05-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}