{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T13:10:01Z","timestamp":1791465001605,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T00:00:00Z","timestamp":1670803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","award":["322\u20102019\u20102456"],"award-info":[{"award-number":["322\u20102019\u20102456"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2023,3]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n To determine whether prior human papillomavirus (HPV) vaccination contributes to preterm birth risk.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Population\u2010based retrospective cohort study.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Denmark.<\/jats:p>\n <\/jats:sec>\n \n Population<\/jats:title>\n A cohort of 243\u2009136 primiparous females born in the period 1961\u20132004 who had a singleton delivery at >22\u2009weeks of gestation occurring from October 2006 to December 2018.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n High\u2010quality nationwide registries were linked to provide information on demographics, birth outcomes, HPV vaccination status, smoking, body mass index (BMI), and cervical lesions and treatment history.<\/jats:p>\n <\/jats:sec>\n \n Main outcome measures<\/jats:title>\n We assessed the association between HPV vaccination status and spontaneous preterm birth using logistic regression. To address age at vaccination, we performed a stratified analysis by vaccination before and after 17\u2009years of age.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n In age\u2010adjusted and fully adjusted models, there was a nonsignificant difference in the odds of spontaneous preterm birth between vaccinated and unvaccinated women (OR\u00a01.05 (95%\u00a0CI 0.99\u20131.12) and OR\u00a01.04 (95%\u00a0CI 0.98\u20131.10), respectively). There was no difference in the odds of spontaneous preterm birth in relation to time between vaccination and pregnancy. In contrast, compared with unvaccinated women, the odds of preterm birth were lower among women vaccinated before the age of 17\u2009years (fully adjusted OR\u00a00.87, 95%\u00a0CI 0.75\u20131.00). This association was not present for women vaccinated at \u226517\u2009years of age.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n In this large, population\u2010based cohort, we found reduced odds of spontaneous preterm birth among women vaccinated against HPV at an early age compared with women who were unvaccinated. It seems conceivable that HPV vaccination may not only reduce the incidence of cervical cancer and severe precursors, but also reduce the risk of preterm birth related to HPV infection.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/1471-0528.17349","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T02:17:42Z","timestamp":1669342662000},"page":"358-365","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Spontaneous preterm birth risk among\n HPV<\/scp>\n \u2010vaccinated and \u2010unvaccinated women: a nationwide retrospective cohort study of over 240\u2009000 singleton births"],"prefix":"10.1111","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6869-2870","authenticated-orcid":false,"given":"Elisabeth","family":"McClymont","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of British Columbia Vancouver British Columbia Canada"},{"name":"Department of Obstetrics & Gynecology University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette T.","family":"Faber","sequence":"additional","affiliation":[{"name":"Virus, Lifestyle and Genes, Danish Cancer Society Research Center Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2920-5005","authenticated-orcid":false,"given":"Federica","family":"Belmonte","sequence":"additional","affiliation":[{"name":"Statistics and Data Analysis, Danish Cancer Society Research Center Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne K.","family":"Kjaer","sequence":"additional","affiliation":[{"name":"Virus, Lifestyle and Genes, Danish Cancer Society Research Center Copenhagen Denmark"},{"name":"Department of Gynecology Rigshospitalet, University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,12]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"March of dimes; The partnership for maternal, newborn, and child health; save the children. Born Too Soon: The global action report on preterm birth","author":"World Health Organization","year":"2012"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(18)30451-0"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2013.301523"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2007.08.005"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3086036"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa054"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2014.09.002"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.25308"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003641"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.12688\/wellcomeopenres.15140.1"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa106"},{"issue":"3","key":"e_1_2_12_13_1","first-page":"320","article-title":"The Danish medical birth registry","volume":"45","author":"Knudsen LB","year":"1998","journal-title":"Dan Med Bull"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494811401482"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810394718"},{"issue":"3","key":"e_1_2_12_16_1","first-page":"798\u2010f","article-title":"Data resource profile: the Danish National Prescription Registry","volume":"46","author":"Potteg\u00e5rd A","year":"2017","journal-title":"Int J Epidemiol"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810387965"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810394715"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810393563"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0962280206074463"},{"key":"e_1_2_12_21_1","volume-title":"R: A language and environment for statistical computing","author":"R Core Team","year":"2021"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2021.1936860"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2021.106473"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix797"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02178-4"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1917338"}],"container-title":["BJOG: An International Journal of Obstetrics & Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.17349","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1471-0528.17349","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.17349","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T23:18:38Z","timestamp":1692400718000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/1471-0528.17349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,12]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1111\/1471-0528.17349"],"URL":"https:\/\/doi.org\/10.1111\/1471-0528.17349","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,12]]},"assertion":[{"value":"2022-05-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}