{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T02:08:57Z","timestamp":1787969337654,"version":"build-2784847793"},"reference-count":56,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T00:00:00Z","timestamp":1676851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["114024144"],"award-info":[{"award-number":["114024144"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Several human randomised controlled trials (RCTs) are investigating the effects of statins on pre\u2010eclampsia (PE) and fetal growth restriction (FGR). This cross\u2010species meta\u2010analysis summarises the preclinical evidence of statin use for PE and FGR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Evaluate the effects of statins on maternal blood pressure (MBP) and birthweight (BW) in pregnancies complicated by PE or FGR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Search Strategy<\/jats:title><jats:p>PubMed and <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/embase.com\">Embase.com<\/jats:ext-link> were searched on 10 May 2022 using \u2018statins\u2019 and \u2018pregnancy\u2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Selection Criteria<\/jats:title><jats:p>We included RCTs and cohorts with matched control groups as well as animal studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Collection and Analysis<\/jats:title><jats:p>The main outcomes were MBP in mmHg and BW in grams. The standardised mean difference (SMD) with a 95% confidence interval (CI) was calculated. Subgroup analyses on species, statin, dose, timing and route of administration were performed if subgroups included at least three studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Results<\/jats:title><jats:p>Our data included one human and 12 animal studies. Prenatal administration of statins significantly reduced MBP during pregnancy (SMD\u00a0\u2009\u22122.49\u2009mmHg [95% CI \u22124.26 to \u22120.71], <jats:italic>p<\/jats:italic>\u00a0=\u20090.01). There was no significant effect of statins on BW (SMD 0.69 [95% CI \u22120.65 to 2.03], <jats:italic>p<\/jats:italic>\u00a0=\u20090.28). Our subgroup analyses showed no effect on MBP of different doses, species or route of administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our cross\u2010species meta\u2010analyses demonstrate that statins only reduce maternal blood pressure in rodent pregnancies complicated by pre\u2010eclampsia or fetal growth restriction and have no effect on birthweight across species. The broad confidence intervals, inconsistent direction of the observed effects across the studies and large risk of bias lead us to conclude that a solid base for further human RCTs is lacking.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.17393","type":"journal-article","created":{"date-parts":[[2023,1,22]],"date-time":"2023-01-22T11:39:42Z","timestamp":1674387582000},"page":"577-585","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Statins in pre\u2010eclampsia or fetal growth restriction: A systematic review and meta\u2010analysis on maternal blood pressure and fetal growth across species"],"prefix":"10.1111","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5914-4186","authenticated-orcid":false,"given":"Lotte","family":"Meijerink","sequence":"first","affiliation":[{"name":"Department of Woman and Baby University Medical Centre Utrecht, location Wilhelmina Children's Hospital  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim E.","family":"Wever","sequence":"additional","affiliation":[{"name":"Department for Health Evidence, SYstematic Review Center for Laboratory animal Experimentation (SYRCLE), Radboud Institute for Health Sciences Radboud University Medical Centre  Nijmegen The Netherlands"},{"name":"Department of Anaesthesiology, Radboud Institute for Health Sciences Radboud University Medical Centre  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6587-1320","authenticated-orcid":false,"given":"Fieke","family":"Terstappen","sequence":"additional","affiliation":[{"name":"Department of Woman and Baby University Medical Centre Utrecht, location Wilhelmina Children's Hospital  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wessel","family":"Ganzevoort","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Amsterdam University Medical Centres, Amsterdam Reproduction and Development Research Institute University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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