{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:16:26Z","timestamp":1787508986608,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,3,5]],"date-time":"2023-03-05T00:00:00Z","timestamp":1677974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003100","name":"F\u00e9d\u00e9ration Fran\u00e7aise de Cardiologie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003100","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006138","name":"Soci\u00e9t\u00e9 Fran\u00e7aise d\u2019Hypertension Art\u00e9rielle","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006138","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the risk of gestational hypertension (GH) and pre\u2010eclampsia (PE) during a second pregnancy after occurrence during a first pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>CONCEPTION is a French nationwide cohort study that used data from the National Health Data System (SNDS) database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included all women who gave birth for the first time in France in 2010\u20132018 and who subsequently gave birth. We identified GH and PE through hospital diagnoses and the dispensing of anti\u2010hypertensive drugs. The incidence rate ratios (IRR) of all hypertensive disorder of pregnancy (HDP) during the second pregnancy were estimated using Poisson models adjusted for confounding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measures<\/jats:title>\n                    <jats:p>Incidence rate ratios of HDP during the second pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 2\u2009829\u2009274 women included, 238\u2009506 (8.4%) were diagnosed with HDP during their first pregnancy. In women with GH during their first pregnancy, 11.3% (IRR 4.5, 95% confidence interval [CI]\u00a04.4\u20134.7) and 3.4% (IRR\u00a05.0, 95% CI 4.8\u20135.3) developed GH and PE during their second pregnancy, respectively. In women with PE during their first pregnancy, 7.4% (IRR 2.6, 95% CI 2.5\u20132.7) and 14.7% (IRR 14.3, 95% CI 13.6\u201315.0) developed GH and PE during their second pregnancy, respectively. The more severe and earlier the PE during the first pregnancy, the stronger the likelihood of having PE during the second pregnancy. Maternal age, social deprivation, obesity, diabetes and chronic hypertension were all associated with PE recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These results can guide policymaking that focuses on improving counselling for women who wish to become pregnant more than once, by identifying those who would benefit more from tailored management of modifiable risk factors, and heightened surveillance during post\u2010first pregnancies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1471-0528.17424","type":"journal-article","created":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T12:51:56Z","timestamp":1676724716000},"page":"902-912","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Recurrence of hypertensive disorders of pregnancy: results from a nationwide prospective cohort study (CONCEPTION)"],"prefix":"10.1111","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6838-8804","authenticated-orcid":false,"given":"G.","family":"Lailler","sequence":"first","affiliation":[{"name":"Sant\u00e9 Publique France  Saint\u2010Maurice France"},{"name":"Universit\u00e9 Paris Est  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Grave","sequence":"additional","affiliation":[{"name":"Sant\u00e9 Publique France  Saint\u2010Maurice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gabet","sequence":"additional","affiliation":[{"name":"Sant\u00e9 Publique France  Saint\u2010Maurice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Regnault","sequence":"additional","affiliation":[{"name":"Sant\u00e9 Publique France  Saint\u2010Maurice 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