{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T19:14:30Z","timestamp":1789931670438,"version":"4.0.1"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T00:00:00Z","timestamp":1678320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870233"],"award-info":[{"award-number":["81870233"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To clarify the real\u2010world outcomes in pregnant women with Eisenmenger syndrome (ES) in the new therapeutic era and provide a literature review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective case and literature review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary referral hospital (The Second Xiangya Hospital of Central South University).<\/jats:p><\/jats:sec><jats:sec><jats:title>Sample<\/jats:title><jats:p>Thirteen women with ES delivered between 2011 and 2021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Respective study and literature reviews.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcomes measures<\/jats:title><jats:p>Maternal and neonatal mortality and morbidity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>12\/13 (92%) pregnant women were treated with targeted drugs. 9\/13 (69%) of patients had heart failure, but no maternal deaths occurred. 12\/13 (92%) of women chose caesarean delivery. One pregnant woman gave birth at 37<jats:sup>+1<\/jats:sup>\u00a0weeks, and the remaining 12 (92%) patients had preterm birth. 10\/13 (77%) women gave birth to live infants, of which 9\/10 (90%) were low birthweight infants with a mean birthweight of 1575\u2009g. The infant mortality rate was 1\/10 (10%). Cardiac functional class improved during pregnancy, probably due to therapy; 11\/13 (85%) of the pregnant women were in cardiac functional level III\/IV at admission and 12 (92%) were in cardiac functional class II\/III at discharge. Our literature review identified 72 cases of pregnancy with ES from 11 studies, which were characterised by a low rate of targeted drug use (28%) and a high maternal mortality rate of 24% in the perinatal period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our case series and literature review suggest that targeted drugs may be key to improving maternal mortality in ES.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.17427","type":"journal-article","created":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T17:52:14Z","timestamp":1676742734000},"page":"923-931","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Successful Eisenmenger syndrome\u2010targeted drug therapy in pregnant women: a case series and literature review"],"prefix":"10.1111","volume":"130","author":[{"given":"W.","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine The 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