{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T19:22:57Z","timestamp":1792264977015,"version":"4.4.0"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,3,5]],"date-time":"2023-03-05T00:00:00Z","timestamp":1677974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008644","name":"Faculty of Medicine, McGill University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008644","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004411","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Our aim was to evaluate the ability of arterial stiffness parameters to predict pre\u2010eclampsia early compared with peripheral blood pressure, uterine artery Doppler and established angiogenic biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Tertiary care antenatal clinics in Montreal, Canada.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>Women with singleton high\u2010risk pregnancies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In the first trimester, arterial stiffness was measured by applanation tonometry, along with peripheral blood pressure and serum\/plasma angiogenic biomarkers; uterine artery Doppler was measured in the second trimester. The predictive ability of different metrics was assessed through multivariate logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measures<\/jats:title>\n                    <jats:p>Arterial stiffness (carotid\u2010femoral pulse wave velocity, carotid\u2010radial pulse wave velocity) and wave reflection (augmentation index, reflected wave start time), peripheral blood pressure, ultrasound indices of velocimetry and circulating angiogenic biomarker concentrations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In this prospective study, among 191 high\u2010risk pregnant women, 14 (7.3%) developed pre\u2010eclampsia. A first\u2010trimester 1\u00a0m\/s increase in carotid\u2010femoral pulse wave velocity was associated with 64% increased odds (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05), and a 1\u2010millisecond increase in time to wave reflection with 11% decreased odds for pre\u2010eclampsia (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01). The area under the curve of arterial stiffness, blood pressure, ultrasound indices and angiogenic biomarkers was 0.83 (95% confidence interval [CI] 0.74\u20130.92), 0.71 (95% CI 0.57\u20130.86), 0.58 (95% CI 0.39\u20130.77), and 0.64 (95% CI 0.44\u20130.83), respectively. With a 5% false\u2010positive rate, blood pressure had a sensitivity of 14% for pre\u2010eclampsia and arterial stiffness a sensitivity of 36%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Arterial stiffness predicted pre\u2010eclampsia earlier and with greater ability than blood pressure, ultrasound indices or angiogenic biomarkers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1471-0528.17430","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T09:55:27Z","timestamp":1676886927000},"page":"932-940","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Arterial stiffness for the early prediction of pre\u2010eclampsia compared with blood pressure, uterine artery Doppler and angiogenic biomarkers: a prospective cohort study"],"prefix":"10.1111","volume":"130","author":[{"given":"K.","family":"Phan","sequence":"first","affiliation":[{"name":"Division of Experimental Medicine, Department of Medicine McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. H.","family":"Gomez","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Department of Medicine McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Gorgui","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Department of Medicine McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"El\u2010Messidi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Gagnon","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. A.","family":"Abenhaim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Rahme","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology, Department of Medicine McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4774-2549","authenticated-orcid":false,"given":"S. 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