{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T20:32:33Z","timestamp":1789763553209,"version":"4.0.1"},"reference-count":55,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,4,2]],"date-time":"2023-04-02T00:00:00Z","timestamp":1680393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To study whether the occurrence and type of placental lesions vary according to the time of onset of COVID\u201019 in pregnant women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Case\u2013control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Departments of Gynaecology\u2010Obstetrics and Pathology, Strasbourg University Hospital, France.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Cases were 49 placentas of women with COVID\u201019. Controls were 50 placentas from women who had a past history of molar pregnancy. COVID\u201019 placentas were categorised based on whether birth occurred at more or less than 14\u2009days post\u2010infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Comparison between case and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Maternal and neonatal outcomes were recorded. Macroscopic and microscopic examination of the placentas was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The rate of vascular complications was higher in the COVID groups than in the controls (8 [16.3%] versus 1 [2%], <jats:italic>p<\/jats:italic>\u2009=\u20090.02). Signs of fetal (22[44.9%] versus 13 [26%], <jats:italic>p<\/jats:italic>\u2009=\u20090.05) and maternal (44 [89.8%] versus 36 [72.0%], <jats:italic>p<\/jats:italic>\u2009=\u20090.02) vascular malperfusion and signs of inflammation (11 [22.4%] versus 3 [6.0%], <jats:italic>p<\/jats:italic>\u2009=\u20090.019) were significantly more common in the COVID\u201019 groups than in the control group. Fetal malperfusion lesions (9 [39.1%] versus 13 [50.0%], <jats:italic>p<\/jats:italic>\u2009=\u20090.45) and placental inflammation (4 [17.4%] versus 7 [26.9%], <jats:italic>p<\/jats:italic>\u2009=\u20090.42) rates were not significantly different between the two COVID\u201019 groups. Chronic villitis was significantly more common when the delivery occurred &gt;14\u2009days after infection than in the group that delivered &lt;14\u2009days after infection (7 [26.9%] versus 1 [4.4%], <jats:italic>p<\/jats:italic>\u2009=\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study suggests that SARS\u2010COV\u20102 induces placental lesions that evolve after disease recovery, especially with the development of inflammatory lesions, such as chronic villitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.17458","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T06:49:01Z","timestamp":1680504541000},"page":"949-958","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Development of placental lesions after recovery from COVID\u201019 during pregnancy: case\u2013control study"],"prefix":"10.1111","volume":"130","author":[{"given":"C.","family":"Milot","sequence":"first","affiliation":[{"name":"Obstetrics and Gynaecology Department Strasbourg University Hospitals  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Koch","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Department Strasbourg University Hospitals  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Averous","sequence":"additional","affiliation":[{"name":"Pathology Department Strasbourg University Hospitals  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Mayeur","sequence":"additional","affiliation":[{"name":"Pathology Department Strasbourg University Hospitals  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4273-6553","authenticated-orcid":false,"given":"P.","family":"Deruelle","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Department Strasbourg University Hospitals  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.743022"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2021.e06393"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2021.166248"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.13308"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10735-021-09970-4"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph182010931"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crwh.2020.e00243"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2021.1050"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.102951"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajogmf.2020.100133"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajogmf.2020.100145"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.04.039"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14215"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/v13050723"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-021-01067-6"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/1093526620925569"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000511324"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-021-03097-3"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2021-0246-SA"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2021.01.049"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.10.020"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2020.08.018"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.685919"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2021.1977791"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqaa089"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajogmf.2021.100468"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2021.10.010"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001772"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2021.115595"},{"key":"e_1_2_12_31_1","volume-title":"COVID 19. 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