{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T09:58:56Z","timestamp":1769853536887,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T00:00:00Z","timestamp":1681689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the neurodevelopmental outcomes of preterm twins at 5\u00bd\u2009years by chorionicity of pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective nationwide population\u2010based EPIPAGE2 (Etude Epid\u00e9miologique sur les Petits \u00c2ges Gestationnels) cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>A total of 546 maternity units in France, between March and December 2011.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>A total of 1126 twins eligible for follow\u2010up at 5\u00bd\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The association of chorionicity with outcomes was analysed using multivariate regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Survival at 5\u00bd\u2009years with or without neurodevelopmental disabilities (comprising cerebral palsy, visual, hearing, cognitive deficiency, behavioural difficulties or developmental coordination disorders) were described and compared by chorionicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 1126 twins eligible for follow\u2010up at 5\u00bd\u2009years, 926 (82.2%) could be evaluated: 228 monochorionic (MC) and 698 dichorionic (DC). Based on chronicity and gestational age of birth, we found no significant differences for severe neonatal morbidity. The rates of moderate\/severe neurobehavioral disabilities were similar in infants from DC pregnancies versus infants from MC pregnancies (OR\u20091.22, 95%\u2009CI 0.65\u20132.28). By gestational age and without twin\u2013twin transfusion syndrome (TTTS), no difference according to chorionicity was found for all neurodevelopmental outcome measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The neurodevelopmental outcomes among preterm twins at 5\u00bd\u2009years is similar, irrespective of chorionicity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.17460","type":"journal-article","created":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T04:10:34Z","timestamp":1681791034000},"page":"1047-1058","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Chorionicity and neurodevelopmental outcomes at 5\u00bd\u2009years among twins born preterm: the EPIPAGE2 cohort study"],"prefix":"10.1111","volume":"130","author":[{"given":"Delphine","family":"Hoarau","sequence":"first","affiliation":[{"name":"Department of Neonatology North Hospital, Assistance Publique des H\u00f4pitaux de Marseille  Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1801-9944","authenticated-orcid":false,"given":"Barth\u00e9l\u00e9my","family":"Tosello","sequence":"additional","affiliation":[{"name":"Department of Neonatology North Hospital, Assistance Publique des H\u00f4pitaux de Marseille  Marseille France"},{"name":"Aix\u2010Marseille Univ, CNRS, EFS, ADES  Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1542-504X","authenticated-orcid":false,"given":"Julie","family":"Blanc","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Nord Hospital, Assistance Publique des H\u00f4pitaux de Marseille  Marseille France"},{"name":"EA\u20093279, CEReSS \u2013 Health Service Research and Quality of Life Centre Aix\u2010Marseille University  Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9654-8104","authenticated-orcid":false,"given":"Elsa","family":"Lorthe","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, Epidemiology and Statistics Research Center\/CRESS, INSERM, INRA  Paris France"},{"name":"Unit of Population Epidemiology, Department of Primary Care Medicine Geneva University Hospitals  Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"Foix\u2010L'Helias","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, Epidemiology and Statistics Research Center\/CRESS, INSERM, INRA  Paris France"},{"name":"Department of Neonatology Trousseau Hospital, Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claude","family":"D'Ercole","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Nord Hospital, Assistance Publique des H\u00f4pitaux de Marseille  Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Winer","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Centre d'Investigation Clinique M\u00e8re Enfant University Hospital, Institut National de la Recherche Agronomique (INRA), Unit\u00e9 Mixte de Recherche 1280 Physiologie des Adaptations Nutritionnelles  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damien","family":"Subtil","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Jeanne de Flandre Hospital, Lille, France, Equipe d'Accueil 2694, P\u00f4le de Recherche et d'Enseignement Sup\u00e9rieur University of Lille Nord de France  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Goffinet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, Epidemiology and Statistics Research Center\/CRESS, INSERM, INRA  Paris France"},{"name":"Department of Obstetrics and Gynaecology Trousseau Hospital, Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"Kayem","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, Epidemiology and Statistics Research Center\/CRESS, INSERM, INRA  Paris France"},{"name":"Department of Obstetrics and Gynaecology Trousseau Hospital, Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"No\u00e9mie","family":"Resseguier","sequence":"additional","affiliation":[{"name":"EA\u20093279, CEReSS \u2013 Health Service Research and Quality of Life Centre Aix\u2010Marseille University  Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Gire","sequence":"additional","affiliation":[{"name":"Department of Neonatology North Hospital, Assistance Publique des H\u00f4pitaux de Marseille  Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the EPIPAGE2 Obstetric Writing Group*","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,4,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogoh.2019.01.013"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0368-2315(09)73555-0"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.04.031"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2012.02.001"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2007.01556.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2006.11.002"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.16170"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.12703"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-018-0190-z"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/children9020239"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n741"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deab029"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyaa282"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0012162200001511"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-4372"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0031512517729951"},{"issue":"11","key":"e_1_2_11_18_1","first-page":"1232","article-title":"Visual acuity and work and leisure abilities","volume":"56","author":"Zanlonghi X","year":"2006","journal-title":"Rev Prat"},{"key":"e_1_2_11_19_1","unstructured":"WechslerD.Pearson Clinical & Talent Assessment. WPPSI\u2010IV e \u00e9chelle d'intelligence de Wechsler pour enfants. 4\u00e8me \u00e9dition.2014[cited 2022 Jun 23] Available from:https:\/\/nam11.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.pearsonclinical.fr%2Fwppsiiv&data=05%7C01%7Co.pyne%40elsevier.com%7Caa0e7f2049e64760293908a60bcef05%7C9274ee3f94254109a27f9fb15c10675d%7C0%7C0%7C63792866183165267%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6k1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=EDWI9TVmmOovyalAkd9kjaLo49FYY2tEor5jkJqlcM%3D&reserved=0"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.1997.tb01545.x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-200111000-00015"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.175.5.444"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgyn.2015.08.009"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14832"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2003.07.004"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-007-0422-6"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8070944"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/children8110943"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12783"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e318212faa0"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2013.01.014"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2015.00159"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-020-0795-8"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.17460","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T19:07:42Z","timestamp":1692212862000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/1471-0528.17460"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,17]]},"references-count":32,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1111\/1471-0528.17460"],"URL":"https:\/\/doi.org\/10.1111\/1471-0528.17460","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,17]]},"assertion":[{"value":"2022-11-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}