{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T18:36:33Z","timestamp":1788978993271,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T00:00:00Z","timestamp":1680480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The role of maternal age in the development of non\u2010chromosomal congenital anomalies (NCAs) is under debate. Therefore, the primary aim of this study was to identify the age groups at risk for NCAs. The secondary aim was to perform a detailed analysis of the relative frequency of various anomalies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>National population\u2010based study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>The Hungarian Case\u2010Control Surveillance of Congenital Anomalies (CAs) between 1980 and 2009.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population or Sample<\/jats:title><jats:p>A cohort of 31\u2009128 cases with confirmed NCAs was compared with Hungary's total of 2\u2009808\u2009345 live births.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinicians prospectively reported cases after delivery. Data were analysed by non\u2010linear logistic regression. Risk\u2010increasing effect of young and advanced maternal age was determined by each NCA group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>These were the total number of NCAs: cleft lip and palate, circulatory, genital, musculoskeletal, digestive, urinary, eye, ear, face, and neck, nervous system, and respiratory system anomalies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The occurrence of NCAs in our database was lowest between 23 and 32\u2009years of maternal age at childbirth. The relative risk (RR) of any NCA was 1.2 (95% CI 1.17\u20131.23) and 1.15 (95% CI 1.11\u20131.19) in the very young and advanced age groups, respectively. The respective results for the circulatory system were RR\u00a0=\u00a01.07 (95% CI 1.01\u20131.13) and RR\u00a0=\u00a01.33 (95% CI 1.24\u20131.42); for cleft lip and palate RR\u00a0=\u00a01.09 (95% CI 1.01\u20131.19) and RR\u00a0=\u00a01.45 (95% CI 1.26\u20131.67); for genital organs RR\u00a0=\u00a01.15 (95% CI 1.08\u20131.22) and RR\u00a0=\u00a01.16 (95% CI 1.04\u20131.29); for the musculoskeletal system RR\u00a0=\u00a01.17 (95% CI 1.12\u20131.23) and RR\u00a0=\u00a01.29 (95% CI 1.14\u20131.44); and for the digestive system RR\u00a0=\u00a01.23 (95% CI 1.14\u20131.31) and RR\u00a0=\u00a01.16 (95% CI 1.04\u20131.29).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Very young and advanced maternal ages are associated with different types of NCAs. Therefore, screening protocols should be adjusted for these risk groups.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.17461","type":"journal-article","created":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T05:14:31Z","timestamp":1680585271000},"page":"1217-1225","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Maternal age is highly associated with non\u2010chromosomal congenital anomalies: Analysis of a population\u2010based case\u2010control database"],"prefix":"10.1111","volume":"130","author":[{"given":"Bogl\u00e1rka","family":"Peth\u0151","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Semmelweis University  Budapest Hungary"},{"name":"Centre for Translational Medicine Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1kos","family":"M\u00e1trai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Semmelweis University  Budapest Hungary"},{"name":"Centre for Translational Medicine Semmelweis University  Budapest Hungary"},{"name":"Faculty of Health Sciences University of P\u00e9cs  P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gergely","family":"Ag\u00f3cs","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine Semmelweis University  Budapest Hungary"},{"name":"Department of Biophysics and Radiation Biology Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e1niel S\u00e1ndor","family":"Veres","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine Semmelweis University  Budapest Hungary"},{"name":"Department of Biophysics and Radiation Biology Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Harnos","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine Semmelweis University  Budapest Hungary"},{"name":"Department of Biostatics University of Veterinary Medicine Budapest  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szil\u00e1rd","family":"V\u00e1ncsa","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine Semmelweis University  Budapest Hungary"},{"name":"Institute for Translational Medicine, Szent\u00e1gothai Research Centre Medical School, University of P\u00e9cs  P\u00e9cs Hungary"},{"name":"Institute for Pancreatic Diseases Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferenc","family":"B\u00e1nhidy","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Semmelweis University  Budapest Hungary"},{"name":"Centre for Translational Medicine Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Hegyi","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine Semmelweis University  Budapest Hungary"},{"name":"Institute for Translational Medicine, Szent\u00e1gothai Research Centre Medical School, University of P\u00e9cs  P\u00e9cs Hungary"},{"name":"Institute for Pancreatic Diseases Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00e1ndor","family":"\u00c1cs","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Semmelweis University  Budapest Hungary"},{"name":"Centre for Translational Medicine Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,3]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.1589"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20294"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-90-481-9485-8_20"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61728-0"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6902a1"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2017.1326901"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6602a1"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016340903505748"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.1304"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2009.02227.x"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(00)01019-X"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0241364"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1032"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2019.1673359"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/cga.12025"},{"key":"e_1_2_12_18_1","unstructured":"(Platform) EPoRDRER.Hungary. [cited 2022 June 16]. Available from:https:\/\/eu\u2010rd\u2010platform.jrc.ec.europa.eu\/eurocat\/eurocat\u2010members\/registrieshungary_en#:~:text=The%20Hungarian%20Congenital%20Abnormality%20Registry Health%20Development%20under%20government%20financing"},{"key":"e_1_2_12_19_1","unstructured":"GRADEpro. Available from:https:\/\/www.gradepro.org\/"},{"key":"e_1_2_12_20_1","volume-title":"A language and environment for statistical computing","author":"R Core Team","year":"2022"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.2307\/2685469"},{"key":"e_1_2_12_22_1","unstructured":"HarrellJ FrankE.Rms: Regression Modeling Strategies.2021Available from:https:\/\/CRAN.R\u2010project.org\/package=rms"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20065"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.85.5.710"},{"key":"e_1_2_12_25_1","unstructured":"RCOG.Non\u2010invasive Prenatal Testing for Chromosomal Abnormality using Maternal Plasma DNA. Available from:https:\/\/www.rcog.org.uk\/media\/gecpbqau\/sip_15_04032014.pdf"},{"key":"e_1_2_12_26_1","unstructured":"GUIDELINE JS\u2010CCP.Prenatal Screening for Fetal Aneuploidy in Singleton Pregnancies. Available from:https:\/\/www.jogc.com\/article\/S1701\u20102163(16)34961\u20101\/pdf"},{"key":"e_1_2_12_27_1","unstructured":"Guidance A.NIPT Summary of Recommendations. Available from:https:\/\/www.acog.org\/advocacy\/policy\u2010priorities\/non\u2010invasive\u2010prenatal\u2010testing\/current\u2010acog\u2010guidance"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420330209"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(82)90029-7"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/02724936.1997.11747889"},{"issue":"2","key":"e_1_2_12_31_1","first-page":"132","article-title":"Anencephalus in Scotland 1961\u201072","volume":"30","author":"Fedrick J","year":"1976","journal-title":"Br J Prev Soc Med"},{"issue":"8","key":"e_1_2_12_32_1","first-page":"323","article-title":"Epidemiology of neural tube defects, Hawaii, 1986\u20101997","volume":"59","author":"Forrester MB","year":"2000","journal-title":"Hawaii Med J"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000437597.44550.5d"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.15188"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23507"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2019.10.006"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-019-7269-0"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2018.05.004"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.17461","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T07:16:07Z","timestamp":1695107767000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/1471-0528.17461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,3]]},"references-count":37,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1111\/1471-0528.17461"],"URL":"https:\/\/doi.org\/10.1111\/1471-0528.17461","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,3]]},"assertion":[{"value":"2022-08-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}