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Offspring cardiac measurements were assessed by Cardiovascular Magnetic Resonance at 10\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Left and right ventricular end\u2010diastolic volumes (LVEDVs and RVEDVs), and ejection fractions, and left ventricular mass (LVM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Offspring exposed to pre\u2010eclampsia had a lower right ventricular ejection fraction (RVEF) (difference, \u22120.31\u2009SDS; 95%\u2009CI \u22120.60, \u22120.02); however, no associations with other cardiac outcomes were present. Higher maternal diastolic blood pressure (DBP) in early and late pregnancy was associated with lower LVEDVs and RVEDVs (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), with the strongest effect in early pregnancy. No associations of systolic blood pressure (SBP) with offspring outcomes were present. These associations persisted after additional adjustment for birth and child factors. Paternal SBP and DBP were not associated with offspring cardiac outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>No consistent associations of gestational hypertensive disorder status with childhood cardiac outcomes were present. Higher maternal DBP throughout pregnancy was associated with lower childhood LVEDVs and RVEDVs. Stronger maternal\u2013offspring rather than paternal\u2013offspring associations were present, which may suggest that suboptimal maternal gestational haemodynamic adaptations affects offspring cardiac structure through direct intrauterine effects. Further studies are needed to replicate these findings and examine the underlying mechanisms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.17468","type":"journal-article","created":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T09:54:28Z","timestamp":1680688468000},"page":"1226-1237","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Gestational hypertensive disorders and blood pressure and childhood cardiac outcomes: A prospective cohort study"],"prefix":"10.1111","volume":"130","author":[{"given":"Meddy N.","family":"Bongers\u2010Karmaoui","sequence":"first","affiliation":[{"name":"The Generation R Study Group Erasmus University Medical Center Rotterdam  Rotterdam the Netherlands"},{"name":"Department of Pediatrics, Sophia's Children's Hospital Erasmus University Medical Center Rotterdam  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarissa J.","family":"Wiertsema","sequence":"additional","affiliation":[{"name":"The Generation R Study Group Erasmus University Medical Center Rotterdam  Rotterdam the Netherlands"},{"name":"Department of Pediatrics, Sophia's Children's Hospital Erasmus University Medical Center Rotterdam  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemarie G. 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