{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T01:44:15Z","timestamp":1792547055367,"version":"4.5.0"},"reference-count":55,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T00:00:00Z","timestamp":1681171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Umbilical cord blood acid\u2013base sampling is routinely performed at many hospitals. Recent studies have questioned this practice and the association of acidosis with cerebral palsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the associations between the results of umbilical cord blood acid\u2013base analysis at birth and long\u2010term neurodevelopmental outcomes and mortality in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Search strategy<\/jats:title>\n                    <jats:p>We searched six databases using the search strategy: umbilical cord AND outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Selection criteria<\/jats:title>\n                    <jats:p>Randomised controlled trials, cohorts and case\u2013control studies from high\u2010income countries that investigated the association between umbilical cord blood analysis and neurodevelopmental outcomes and mortality from 1\u2009year after birth in children born at term.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data collection and analysis<\/jats:title>\n                    <jats:p>We critically assessed the included studies, extracted data and conducted meta\u2010analyses comparing adverse outcomes between children with and without acidosis, and the mean proportions of adverse outcomes. The certainty of evidence was assessed using the Grading of Recommendations, Assessment, Development and Evaluations approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main results<\/jats:title>\n                    <jats:p>\n                      We have very low confidence in the following findings: acidosis was associated with higher cognitive development scores compared with non\u2010acidosis (mean difference 5.18, 95% CI 0.84\u20139.52;\n                      <jats:italic>n =<\/jats:italic>\n                      two studies). Children with acidosis also showed a tendency towards higher risk of death (relative risk [RR] 5.72, 95% CI 0.90\u201336.27;\n                      <jats:italic>n =<\/jats:italic>\n                      four studies) and CP (RR 3.40, 95% CI 0.86\u201313.39;\n                      <jats:italic>n =<\/jats:italic>\n                      four studies), although this was not statistically significant. The proportion of children with CP was 2.39\/1000 across the studies, assessed as high certainty evidence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Due to low certainty of evidence, the associations between umbilical cord blood gas analysis at delivery and long\u2010term neurodevelopmental outcomes in children remains unclear.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1471-0528.17480","type":"journal-article","created":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T21:48:57Z","timestamp":1681249737000},"page":"1156-1166","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Umbilical cord blood acid\u2013base analysis at birth and long\u2010term neurodevelopmental outcomes in children: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"130","author":[{"given":"Hilde Tinderholt","family":"Myrhaug","sequence":"first","affiliation":[{"name":"Department of Nursing and Health Promotion, Faculty of Health Sciences Oslo Metropolitan University  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Kaasen","sequence":"additional","affiliation":[{"name":"Department of Nursing and Health Promotion, Faculty of Health Sciences Oslo Metropolitan University  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aase Serine Devold","family":"Pay","sequence":"additional","affiliation":[{"name":"Department of Nursing and Health Promotion, Faculty of Health Sciences Oslo Metropolitan University  Oslo Norway"},{"name":"Department of Obstetrics and Gynaecology Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Henriksen","sequence":"additional","affiliation":[{"name":"Department of Nursing and Health Promotion, Faculty of Health Sciences Oslo Metropolitan University  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geir","family":"Smedslund","sequence":"additional","affiliation":[{"name":"Division for Health Services Norwegian Institute of Public Health  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola Didrik","family":"Saugstad","sequence":"additional","affiliation":[{"name":"Department of Paediatric Research University of Oslo  Nydalen Norway"},{"name":"Ann and Robert H. 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