{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:20:13Z","timestamp":1792513213778,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T00:00:00Z","timestamp":1681689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009480","name":"Stichting Vrienden van het Sophia","doi-asserted-by":"publisher","award":["S19\u201012"],"award-info":[{"award-number":["S19\u201012"]}],"id":[{"id":"10.13039\/501100009480","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.pericles-gcp.literatumonline.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To describe the outcomes of preterm born infants with congenital diaphragmatic hernia (CDH; \u226432.0\u2009weeks of gestation) and the associations between prenatal imaging markers and survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Multicentre study in large referral centres.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Infants with an isolated unilateral CDH, live born at 32.0\u2009weeks or less of gestation, between January 2009 and January 2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Neonatal outcomes were evaluated for infants that were expectantly managed during pregnancy and infants that underwent fetoscopic endoluminal tracheal occlusion (FETO) therapy, separately. We evaluated the association between prenatal imaging markers and survival to discharge. Prenatal imaging markers included observed to expected lung\u2010to\u2010head ratio (o\/e LHR), side of the defect, liver position, stomach position grade, and observed to expected total fetal lung volume (o\/e TFLV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measure<\/jats:title><jats:p>Survival to discharge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 53 infants born at 30<jats:sup>+4<\/jats:sup> (interquartile range 29<jats:sup>+1<\/jats:sup>\u201331<jats:sup>+2<\/jats:sup>) weeks. Survival in fetuses expectantly managed during pregnancy was 48% (13\/27) in left\u2010sided CDH and 33% (2\/6) in right\u2010sided CDH. Survival in fetuses that underwent FETO therapy was 50% (6\/12) in left\u2010sided CDH and 25% (2\/8) in right\u2010sided CDH. The o\/e LHR at baseline was positively associated with survival in cases expectantly managed during pregnancy (odds ratio [OR] 1.20, 95% CI 1.07\u20131.42, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), but not in cases that received FETO therapy (OR 1.01, 95% CI 0.88\u20131.15, <jats:italic>p<\/jats:italic>\u2009=\u20090.87). Stomach position grade (<jats:italic>p<\/jats:italic>\u2009=\u20090.03) and o\/e TFLV were associated with survival (<jats:italic>p<\/jats:italic>\u2009=\u20090.02); liver position was not (<jats:italic>p<\/jats:italic>\u2009=\u20090.13).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In infants with CDH born at or before 32\u2009weeks of gestation, prenatal imaging markers of disease severity were associated with postnatal survival.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.17497","type":"journal-article","created":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T04:06:40Z","timestamp":1681790800000},"page":"1403-1411","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Survival in very preterm infants with congenital diaphragmatic hernia and association with prenatal imaging markers: A retrospective cohort study"],"prefix":"10.1111","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0582-1129","authenticated-orcid":false,"given":"Emily J. J.","family":"Horn\u2010Oudshoorn","sequence":"first","affiliation":[{"name":"Division of Neonatology, Department of Paediatrics Erasmus MC University Medical Centre  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca M.","family":"Russo","sequence":"additional","affiliation":[{"name":"Clinical Department of Obstetrics and Gynaecology University Hospitals Leuven  Leuven Belgium"},{"name":"Academic Department of Development and Regeneration, Cluster Woman and Child KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4920-945X","authenticated-orcid":false,"given":"Jan A.","family":"Deprest","sequence":"additional","affiliation":[{"name":"Clinical Department of Obstetrics and Gynaecology University Hospitals Leuven  Leuven Belgium"},{"name":"Academic Department of Development and Regeneration, Cluster Woman and Child KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Kipfmueller","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Paediatric Critical Care Medicine University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annegret","family":"Geipel","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Prenatal Medicine University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Schaible","sequence":"additional","affiliation":[{"name":"Department of Neonatology University Hospital Mannheim  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neysan","family":"Rafat","sequence":"additional","affiliation":[{"name":"Department of Neonatology University Hospital Mannheim  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Gael","family":"Cordier","sequence":"additional","affiliation":[{"name":"Centre Reference Maladie Rare Hernie de Coupole Diaphragmatique  Clamart France"},{"name":"Department of Obstetrics and Gynaecology, Hospital Antoine B\u00e9cl\u00e8re University Paris\u2010Saclay  Clamart France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Benachi","sequence":"additional","affiliation":[{"name":"Centre Reference Maladie Rare Hernie de Coupole Diaphragmatique  Clamart France"},{"name":"Department of Obstetrics and Gynaecology, Hospital Antoine B\u00e9cl\u00e8re University Paris\u2010Saclay  Clamart France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimrah","family":"Abbasi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Mount Sinai Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla P. L.","family":"Chiu","sequence":"additional","affiliation":[{"name":"Division of General and Thoracic Surgery, Department of Surgery The Hospital for Sick Children  Toronto Ontario Canada"},{"name":"Department of Surgery University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem P.","family":"de Boode","sequence":"additional","affiliation":[{"name":"Department of Neonatology Radboud University Medical Centre, Radboud Institute for Health Sciences, Amalia Children's Hospital  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Sikkel","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Radboud University Medical Centre Nijmegen  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina C. 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