{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:48:39Z","timestamp":1790034519929,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T00:00:00Z","timestamp":1684713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K23HL159316"],"award-info":[{"award-number":["K23HL159316"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["K24ES031131"],"award-info":[{"award-number":["K24ES031131"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG022095"],"award-info":[{"award-number":["R01AG022095"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006545","name":"National Institute on Minority Health and Health Disparities","doi-asserted-by":"publisher","award":["R01MD011609"],"award-info":[{"award-number":["R01MD011609"]}],"id":[{"id":"10.13039\/100006545","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine whether women with spontaneous preterm birth (PTB) have increased risks for long\u2010term mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Births in Utah between 1939 and 1977.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>We included women with a singleton live birth \u226520\u2009weeks who survived at least 1\u2009year following delivery. We excluded those who had never lived in Utah, had improbable birthweight\/gestational age combinations, underwent induction (except for preterm membrane rupture) or had another diagnosis likely to cause PTB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Exposed women had \u22651 spontaneous PTB between 20<jats:sup>+0<\/jats:sup>\u2009weeks and 37<jats:sup>+0<\/jats:sup>\u2009weeks. Women with &gt;1 spontaneous PTB were included only once. Unexposed women had all deliveries at or beyond 38<jats:sup>+0<\/jats:sup>\u2009weeks. Exposed women were matched to unexposed women by birth year, infant sex, maternal age group and infant birth order. Included women were followed up to 39\u2009years after index delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Overall and cause\u2010specific mortality risks were compared using Cox regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 29\u2009048 exposed and 57\u2009992 matched unexposed women. There were 3551 deaths among exposed (12.2%) and 6013 deaths among unexposed women (10.4%). Spontaneous PTB was associated with all\u2010cause mortality (adjusted hazard ratio [aHR] 1.26, 95% confidence interval [CI] 1.21\u20131.31), death from neoplasms (aHR 1.10, 95% CI 1.02\u20131.18), circulatory disease (aHR 1.35, 95% CI 1.25\u20131.46), respiratory disease (aHR 1.73, 95% CI 1.46\u20132.06), digestive disease (aHR 1.33, 95% CI 1.12\u20131.58), genito\u2010urinary disease (aHR 1.60, 95% CI 1.15\u20132.23) and external causes (aHR 1.39, 95% CI 1.22\u20131.58).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Spontaneous PTB is associated with modestly increased risks for all\u2010cause and some cause\u2010specific mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.17552","type":"journal-article","created":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T11:25:27Z","timestamp":1684754727000},"page":"1483-1490","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Long\u2010term maternal mortality risk following spontaneous preterm birth: A retrospective cohort study"],"prefix":"10.1111","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5662-6040","authenticated-orcid":false,"given":"Lauren H.","family":"Theilen","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Utah Health  Salt Lake City Utah USA"},{"name":"Intermountain Healthcare, Women and Newborns Clinical Program  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Hammad","sequence":"additional","affiliation":[{"name":"Department of Obstetrics 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