{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T20:48:17Z","timestamp":1771102097694,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,7,2]],"date-time":"2023-07-02T00:00:00Z","timestamp":1688256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004622","name":"KWF Kankerbestrijding","doi-asserted-by":"publisher","award":["10164"],"award-info":[{"award-number":["10164"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To study the impact of premenopausal risk\u2010reducing salpingo\u2010oophorectomy (RRSO), compared with postmenopausal RRSO, on urinary incontinence (UI) \u226510\u2009years later.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Cross\u2010sectional study, nested in a nationwide cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Multicentre in the Netherlands.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>750 women (68% <jats:italic>BRCA1\/2<\/jats:italic> pathogenic variant carriers) who underwent either premenopausal RRSO (\u226445\u2009years, <jats:italic>n<\/jats:italic>\u2009=\u2009496) or postmenopausal RRSO (\u226554\u2009years, <jats:italic>n<\/jats:italic>\u2009=\u2009254). All participants were \u226555\u2009years at the time of the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Urinary incontinence was assessed by the urinary distress inventory\u20106 (UDI\u20106); a score \u226533.3 indicated symptomatic UI. The incontinence impact questionnaire short form (IIQ\u2010SF) was used to assess the impact on women's health\u2010related quality of life (HR\u2010QoL). Differences between groups were analysed using regression analyses adjusting for current age and other confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Differences in UDI\u20106 scores and IIQ\u2010SF scores between women with a premenopausal and a postmenopausal RRSO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Women in the premenopausal RRSO group had slightly higher UDI\u20106 scores compared with women in the postmenopausal RRSO group (<jats:italic>P<\/jats:italic> =\u20090.053), and their risk of symptomatic UI was non\u2010significantly increased (odds ratio [OR] 2.1, 95% confidence interval [95% CI] 0.93\u20134.78). A premenopausal RRSO was associated with a higher risk of stress UI (OR 3.5, 95% CI 1.2\u201310.0) but not with urge UI. The proportions of women with a significant impact of UI on HR\u2010QoL were similar in the premenopausal and postmenopausal RRSO groups (10.4% and 13.0%, respectively; <jats:italic>P =<\/jats:italic> 0.46).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>More than 15\u2009years after premenopausal RRSO, there were no significant differences in overall symptomatic UI between women with a premenopausal and those with a postmenopausal RRSO.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.17591","type":"journal-article","created":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T04:15:30Z","timestamp":1688357730000},"page":"99-108","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Urinary incontinence more than 15\u2009years after premenopausal risk\u2010reducing salpingo\u2010oophorectomy: a multicentre cross\u2010sectional study"],"prefix":"10.1111","volume":"131","author":[{"given":"Lara","family":"Terra","sequence":"first","affiliation":[{"name":"Division of Psychosocial Research and Epidemiology The Netherlands Cancer Institute  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernadette A. M.","family":"Heemskerk\u2010Gerritsen","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Erasmus MC Cancer Institute  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maarten J.","family":"Beekman","sequence":"additional","affiliation":[{"name":"Division of Psychosocial Research and Epidemiology The Netherlands Cancer Institute  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Engelhardt","sequence":"additional","affiliation":[{"name":"Division of Psychosocial Research and Epidemiology The Netherlands Cancer Institute  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marian J. E.","family":"Mourits","sequence":"additional","affiliation":[{"name":"Department of Gynaecologic Oncology University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1062-4485","authenticated-orcid":false,"given":"Helena C.","family":"van Doorn","sequence":"additional","affiliation":[{"name":"Department of Gynaecologic Oncology Erasmus MC Cancer Institute, University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna A.","family":"de Hullu","sequence":"additional","affiliation":[{"name":"Department for Gynecology Radboud University Medical Centre  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantijne H.","family":"Mom","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Oncology Amsterdam University Medical Centre  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte F. M.","family":"Slangen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Maastricht University Medical Centre  Maastricht The Netherlands"},{"name":"GROW\u2010School for Oncology and Developmental Biology  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja N.","family":"Gaarenstroom","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Leiden University Medical Centre  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"van Beurden","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Oncology The Netherlands Cancer Institute  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanine E.","family":"Roeters\u00a0Van\u00a0Lennep","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Erasmus Medical Centre  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleonora B. L.","family":"van Dorst","sequence":"additional","affiliation":[{"name":"Department of Gynaecologic Oncology University Medical Centre Utrecht  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lizet E.","family":"van der Kolk","sequence":"additional","affiliation":[{"name":"Family Cancer Clinic The Netherlands Cancer Institute  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Margriet","family":"Coll\u00e9e","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Erasmus MC Cancer Institute  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marijke R.","family":"Wevers","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Radboud University Medical Centre  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margreet G .E. M.","family":"Ausems","sequence":"additional","affiliation":[{"name":"Division Laboratories, Pharmacy and Biomedical Genetics, Department of Genetics University Medical Centre Utrecht  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaartje","family":"van Engelen","sequence":"additional","affiliation":[{"name":"Department of Human Genetics Amsterdam UMC, Vrije Universiteit Amsterdam  Amsterdam Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irma","family":"van de Beek","sequence":"additional","affiliation":[{"name":"Department for Human Genetics Amsterdam UMC, University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lieke P. V.","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Genetics University of Groningen, University Medical Centre Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christi J.","family":"van Asperen","sequence":"additional","affiliation":[{"name":"Department for Clinical Genetics Leiden University Medical Centre  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Encarna B.","family":"Gomez\u00a0Garcia","sequence":"additional","affiliation":[{"name":"Department for Clinical Genetics Maastricht University Medical Centre  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela H. E. 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