{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:21:27Z","timestamp":1793060487427,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T00:00:00Z","timestamp":1691366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the effect on major postpartum haemorrhage (PPH) of mode of conception, differentiating between naturally conceived pregnancies, fresh embryo in vitro fertilisation (fresh\u2010IVF) and frozen embryo transfer (frozen\u2010IVF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>The French Burgundy Perinatal Network database, including all deliveries from 2006 to 2020, was linked to the regional blood centre database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population or sample<\/jats:title><jats:p>In all, 244\u2009336 women were included, of whom 240\u2009259 (98.3%) were singleton pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The main analyses were conducted in singleton pregnancies, including 237\u2009608 naturally conceived, 1773 fresh\u2010IVF and 878 frozen\u2010IVF pregnancies. Multivariate logistic regression models adjusted on maternal age, body mass index, smoking, parity, induction of labour, hypertensive disorders, diabetes, placenta praevia and\/or accreta, history of caesarean section, mode of delivery, birthweight, birth place and year of delivery, were used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Major PPH was defined as PPH requiring blood transfusion and\/or emergency surgery and\/or interventional radiology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of major PPH was 0.74% (<jats:italic>n<\/jats:italic>\u2009=\u20091749) in naturally conceived pregnancies, 1.92% (<jats:italic>n<\/jats:italic>\u2009=\u200934) in fresh\u2010IVF pregnancies, and 3.30% (<jats:italic>n<\/jats:italic>\u2009=\u200929) in frozen\u2010IVF pregnancies. The risk of major PPH was higher in frozen\u2010IVF pregnancies than in both naturally conceived pregnancies (adjusted odds ratio [aOR] 2.63, 95% CI 1.68\u20134.10) and fresh\u2010IVF pregnancies (aOR 2.78, 95% CI 1.44\u20135.35).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We found that frozen\u2010IVF pregnancies have a higher risk of major PPH and they should be subject to increased vigilance in the delivery room.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.17625","type":"journal-article","created":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T01:48:30Z","timestamp":1691459310000},"page":"300-308","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Major postpartum haemorrhage after frozen embryo transfer: A\u00a0population\u2010based study"],"prefix":"10.1111","volume":"131","author":[{"given":"Am\u00e9lie","family":"Al\u2010Khatib","sequence":"first","affiliation":[{"name":"P\u00f4le de Gyn\u00e9cologie\u2010Obst\u00e9trique et Biologie de la Reproduction Dijon University Hospital  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Sagot","sequence":"additional","affiliation":[{"name":"P\u00f4le de Gyn\u00e9cologie\u2010Obst\u00e9trique et Biologie de la Reproduction Dijon University Hospital  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Cottenet","sequence":"additional","affiliation":[{"name":"Service de Biostatistique et d'Informatique M\u00e9dicale (DIM) Dijon University Hospital  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massinissa","family":"Aroun","sequence":"additional","affiliation":[{"name":"P\u00f4le de Gyn\u00e9cologie\u2010Obst\u00e9trique et Biologie de la Reproduction Dijon University Hospital  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5134-9411","authenticated-orcid":false,"given":"Catherine","family":"Quantin","sequence":"additional","affiliation":[{"name":"Service de Biostatistique et d'Informatique M\u00e9dicale (DIM) Dijon University Hospital  Dijon France"},{"name":"Clinical Epidemiology Unit Inserm, CIC 1432  Dijon France"},{"name":"Clinical Investigation Centre Dijon University Hospital  Dijon France"},{"name":"Biostatistics, Biomathematics, Pharmacoepidemiology and Infectious Diseases (B2PHI), INSERM, UVSQ Institut Pasteur, Universit\u00e9 Paris\u2010Saclay  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1693-2027","authenticated-orcid":false,"given":"Thomas","family":"Desplanches","sequence":"additional","affiliation":[{"name":"P\u00f4le de Gyn\u00e9cologie\u2010Obst\u00e9trique et Biologie de la Reproduction Dijon University Hospital  Dijon France"},{"name":"Geneva School of Health Sciences HES\u2010SO University of Applied Sciences and Arts Western Switzerland  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoac022"},{"key":"e_1_2_11_3_1","unstructured":"Centers for Disease Control and Prevention.Assisted reproductive technology. 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