{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T15:40:08Z","timestamp":1769010008847,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T00:00:00Z","timestamp":1691539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016545","name":"Roche Diagnostics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016545","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess whether aspirin treatment can be discontinued in pregnancies with normal uterine artery pulsatility index (\u226490th percentile) at 24\u201328\u2009weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Post\u2010hoc analysis of a clinical trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Nine maternity hospitals in Spain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population or Sample<\/jats:title><jats:p>Pregnant individuals at high risk of pre\u2010eclampsia at 11\u201313\u2009weeks and normal uterine artery Doppler at 24\u201328\u2009weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All participants received treatment with daily aspirin at a dose of 150\u2009mg. Participants were randomly assigned, in a 1:1 ratio, either to continue aspirin treatment until 36\u2009weeks (control group) or to discontinue aspirin treatment (intervention group), between September 2019 and September 2021. In this secondary analysis, women with a UtAPI &gt;90th percentile at 24\u201328\u2009weeks were excluded. The non\u2010inferiority margin was set at a difference of 1.9% for the incidence of preterm pre\u2010eclampsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Incidence of preterm pre\u2010eclampsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 1611 eligible women, 139 were excluded for UtAPI &gt;90th percentile or if UtAPI was not available. Finally, 804 were included in this post\u2010hoc analysis. Preterm pre\u2010eclampsia occurred in three of 409 (0.7%) women in the aspirin discontinuation group and five of 395 (1.3%) women in the continuation group (\u22120.53; 95% CI \u22121.91 to 0.85), indicating non\u2010inferiority of aspirin discontinuation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Discontinuing aspirin treatment at 24\u201328\u2009weeks in women with a UtAPI \u226490th percentile was non\u2010inferior to continuing aspirin treatment until 36\u2009weeks for preventing preterm pre\u2010eclampsia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.17631","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T09:59:06Z","timestamp":1691575146000},"page":"334-342","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Mid\u2010trimester uterine artery Doppler for aspirin discontinuation in pregnancies at high risk for preterm pre\u2010eclampsia: Post\u2010hoc analysis of <scp>StopPRE<\/scp> trial"],"prefix":"10.1111","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8042-8247","authenticated-orcid":false,"given":"Erika","family":"Bonacina","sequence":"first","affiliation":[{"name":"Maternal Fetal Medicine Unit, Department of Obstetrics Vall d'Hebron Barcelona Hospital Campus, Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2415-1626","authenticated-orcid":false,"given":"Pablo","family":"Garcia\u2010Manau","sequence":"additional","affiliation":[{"name":"Maternal Fetal Medicine Unit, Department of Obstetrics Vall d'Hebron Barcelona Hospital Campus, Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Hospital Universitari de Tarragona Joan XXIII  Tarragona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Caami\u00f1a","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Hospital Universitario Nuestra Se\u00f1ora de Candelaria  Santa Cruz de Tenerife Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c0ngels","family":"Vives","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Consorci Sanitari de Terrassa  Terrassa Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Lopez\u2010Quesada","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Hospital Universitari M\u00fatua Terrassa  Terrassa Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Ricart","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Hospital Universitari Germans Trias i Pujol  Badalona 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