{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T16:49:16Z","timestamp":1783529356409,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T00:00:00Z","timestamp":1692230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To develop and validate a clinical prediction model for outcomes at 5\u2009years of age for children born extremely preterm and receiving active perinatal management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>The EPIPAGE\u20102 national prospective cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>France, 2011.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Live\u2010born neonates between 24<jats:sup>+0<\/jats:sup> and 26<jats:sup>+6<\/jats:sup>\u2009weeks of gestation who received active perinatal management (i.e. birth in a tertiary\u2010level hospital, with antenatal steroids and resuscitation at birth).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prediction model using logistic modelling, including gestational age, small\u2010for gestational\u2010age (SGA) status and sex, was developed. Model performance was assessed through calibration and discrimination, with bootstrap internal validation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Survival without moderate or severe neurodevelopmental disability (NDD) at 5\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 557 neonates included, 401 (72%) survived to 5\u2009years, of which 59% survived without NDD (95%\u2009CI 54% to 63%). Predicted rates of survival without NDD ranged from 45% (95%\u2009CI 33% to 57%), to 56% (95%\u2009CI 49% to 64%) to 64% (95%\u2009CI 57% to 70%) for neonates born at 24, 25 and 26\u2009weeks of gestation, respectively. Predicted rates of survival without NDD were 47% (95%\u2009CI 18% to 76%) and 62% (95%\u2009CI 49% to 76%) for SGA and non\u2010SGA children, respectively. The model showed good calibration (calibration slope 0.85, 95%\u2009CI 0.54 to 1.16; calibration\u2010in\u2010the\u2010large \u22120.0123, 95%\u2009CI \u22120.25 to 0.23) and modest discrimination (C\u2010index 0.59, 95%\u2009CI 0.53 to 0.65).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A simple prediction model using three factors easily known antenatally may help doctors and families in their decision\u2010making for extremely preterm neonates receiving active perinatal management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.17633","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T17:04:36Z","timestamp":1692637476000},"page":"151-156","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Five\u2010year outcomes for extremely preterm babies with active perinatal management: A clinical prediction model"],"prefix":"10.1111","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1176-0991","authenticated-orcid":false,"given":"Caroline","family":"Diguisto","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Universit\u00e9 Sorbonne Paris Nord, Inserm, INRAE, CRESS U1153, EPOP\u00e9  Paris France"},{"name":"Maternit\u00e9 Olympe de Gouges Centre, Hospitalier Regional Universitaire Tours, Universit\u00e9 de Tours  Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4143-1977","authenticated-orcid":false,"given":"Andrei Scott","family":"Morgan","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Universit\u00e9 Sorbonne Paris Nord, Inserm, INRAE, CRESS U1153, EPOP\u00e9  Paris France"},{"name":"Department of Neonatal Medicine H\u00f4pital Nord, Association Publique H\u00f4pitaux de Marseille  Marseille 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