{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:10:19Z","timestamp":1790791819852,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T00:00:00Z","timestamp":1695600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100011102","name":"Seventh Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003123","name":"Fetal Medicine Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003123","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011033","name":"Thermo Fisher Scientific","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To report the predictive performance for preterm birth (PTB) of the Fetal Medicine Foundation (FMF) triple test and National Institute for health and Care Excellence (NICE) guidelines used to screen for pre\u2010eclampsia and examine the impact of aspirin in the prevention of PTB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Secondary analysis of data from the SPREE study and the ASPRE trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Multicentre studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>In SPREE, women with singleton pregnancies had screening for preterm pre\u2010eclampsia at 11\u201313\u2009weeks of gestation by the FMF method and NICE guidelines. There were 16\u2009451 pregnancies that resulted in delivery at \u226524\u2009weeks of gestation and these data were used to derive the predictive performance for PTB of the two methods of screening. The results from the ASPRE trial were used to examine the effect of aspirin in the prevention of PTB in the population from SPREE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Comparison of performance of FMF method and NICE guidelines for pre\u2010eclampsia in the prediction of PTB and use of aspirin in prevention of PTB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measure<\/jats:title><jats:p>Spontaneous PTB (sPTB), iatrogenic PTB for pre\u2010eclampsia (iPTB\u2010PE) and iatrogenic PTB for reasons other than pre\u2010eclampsia (iPTB\u2010noPE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Estimated incidence rates of sPTB, iPTB\u2010PE and iPTB\u2010noPE were 3.4%, 0.8% and 1.6%, respectively. The corresponding detection rates were 17%, 82% and 25% for the triple test and 12%, 39% and 19% for NICE guidelines, using the same overall screen positive rate of 10.2%. The estimated proportions prevented by aspirin were 14%, 65% and 0%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prediction of sPTB and iPTB\u2010noPE by the triple test was poor and poorer by the NICE guidelines. Neither sPTB nor iPTB\u2010noPE was reduced substantially by aspirin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.17673","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T03:31:02Z","timestamp":1695699062000},"page":"483-492","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["First\u2010trimester prediction of preterm pre\u2010eclampsia and prophylaxis by aspirin: Effect on spontaneous and iatrogenic preterm birth"],"prefix":"10.1111","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1266-0711","authenticated-orcid":false,"given":"Kypros H.","family":"Nicolaides","sequence":"first","affiliation":[{"name":"Fetal Medicine Research Institute King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Argyro","family":"Syngelaki","sequence":"additional","affiliation":[{"name":"Fetal Medicine Research Institute King's College Hospital  London UK"},{"name":"Institute of Women and Children's Health, School of Life Course and Population Sciences King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liona C.","family":"Poon","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel L.","family":"Rolnik","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, School of Clinical Sciences Monash University  Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Yi","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology St Mary's Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Wright","sequence":"additional","affiliation":[{"name":"Institute of Health Research University of Exeter  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Wright","sequence":"additional","affiliation":[{"name":"Institute of Health Research University of Exeter  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,25]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2109523"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1704559"},{"key":"e_1_2_13_4_1","volume-title":"National Collaborating Centre for Women's and Children's health (UK). 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