{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T07:22:15Z","timestamp":1779261735542,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate whether women with unexplained recurrent pregnancy loss have impaired arterial vascular health compared with controls, and to evaluate whether this is modifiable by exercise.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Experimental case\u2013control pilot study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>University medical centre in the Netherlands.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Twelve women with unexplained recurrent pregnancy loss, 11 nulliparous women and 19 primiparous women with a history of uncomplicated pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In all three groups we measured baseline characteristics, metabolic components and arterial vascular health, and repeated this in women with unexplained recurrent pregnancy loss after 1\u2009month of protocolled and supervised cycle training.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Differences in arterial vascular health between women with unexplained recurrent pregnancy loss and controls, and the effect of exercise on arterial vascular health in women with unexplained recurrent pregnancy loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Women with unexplained recurrent pregnancy loss have a significantly increased carotid intima media thickness in comparison with both controls (both <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), a significantly decreased brachial endothelial dependent flow\u2010mediated vasodilation in comparison with both controls (nulliparous: <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01; primiparous: <jats:italic>P<\/jats:italic>\u2009=\u20090.05) and a significantly decreased femoral endothelial dependent flow\u2010mediated vasodilation in comparison with primiparous women (<jats:italic>P<\/jats:italic>\u2009=\u20090.01). The endothelium independent glyceryl trinitrate response was similar in all groups. With 1\u2009month of exercise, the carotid intima media thickness decreased significantly by 7% (<jats:italic>P<\/jats:italic>\u2009=\u20090.05) and the femoral FMD increased significantly by 10% (<jats:italic>P<\/jats:italic>\u2009=\u20090.01) in women with unexplained recurrent pregnancy loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Women with unexplained recurrent pregnancy loss have an impaired vascular health in comparison with controls. This impaired arterial vascular health can be improved by exercise.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.17688","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T07:12:33Z","timestamp":1697613153000},"page":"777-785","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Unexplained recurrent pregnancy loss and markers of arterial vascular health: An experimental case\u2013control study"],"prefix":"10.1111","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5640-0925","authenticated-orcid":false,"given":"Janneke","family":"Donckers","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Radboud University Medical Centre  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4592-4288","authenticated-orcid":false,"given":"Joris","family":"van Drongelen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Radboud University Medical Centre  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc E. A.","family":"Spaanderman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Radboud University Medical Centre  Nijmegen The Netherlands"},{"name":"Research School GROW Maastricht University Medical Centre  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph R.","family":"Scholten","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Radboud University Medical Centre  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,18]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69204-0"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.09.023"},{"key":"e_1_2_12_4_1","unstructured":"Dutch Society of Obstetrics and Gynaecology (NVOG).Guidelines: recurrent pregnancy loss[cited 2021 Apr 4]. 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