{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T19:11:26Z","timestamp":1770750686823,"version":"3.50.0"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T00:00:00Z","timestamp":1697068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the risk of adverse pregnancy outcomes between twin\u2010born and singleton\u2010born women. We also evaluated whether in utero exposure to pre\u2010eclampsia or preterm delivery affected adverse pregnancy outcomes in women's own pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Population\u2010based cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Medical Birth Registry of Norway 1967\u20132020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>9184 twin\u2010born and 492\u2009894 singleton\u2010born women during 1967\u20132005, with their later pregnancies registered during 1981\u20132020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from an individual's birth were linked to their later pregnancies. We used generalised linear models with log link binomial distribution to obtain exponentiated regression coefficients that estimated relative risks (RRs) with 95% confidence intervals (CIs) for associations between twin\u2010 or singleton\u2010born women and later adverse pregnancy outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Pre\u2010eclampsia, preterm delivery or perinatal loss in twin\u2010born compared with singleton\u2010born women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no increased risk for adverse outcomes in twin\u2010born compared with singleton\u2010born women: adjusted RRs for pre\u2010eclampsia were 1.00 (95% CI 0.93\u20131.09), for preterm delivery 0.96 (95% CI 0.90\u20131.02) and for perinatal loss 1.00 (95% CI 0.84\u20131.18). Compared with singleton\u2010born women exposed to pre\u2010eclampsia in utero, twin\u2010born women exposed to pre\u2010eclampsia had lower risk of adverse outcomes in their own pregnancies; the aRR for pre\u2010eclampsia was 0.73 (95% CI 0.58\u20130.91) and for preterm delivery was 0.71 (95% CI 0.56\u20130.90). Compared with preterm singleton\u2010born women, preterm twin\u2010born women did not differ in terms of risk of pre\u2010eclampsia (aRR 1.05, 95% CI 0.92\u20131.21) or perinatal loss (aRR 0.99, 95% CI 0.71\u20131.37) and had reduced risk of preterm delivery (RR 0.83, 95% CI 0.74\u20130.94).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Twin\u2010born women did not differ from singleton\u2010born women in terms of risk of adverse pregnancy outcomes. Twin\u2010born women exposed to pre\u2010eclampsia in utero, had a lower risk of pre\u2010eclampsia and preterm delivery compared with singleton\u2010born women exposed to pre\u2010eclampsia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.17690","type":"journal-article","created":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T01:45:15Z","timestamp":1697161515000},"page":"750-758","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Risk of adverse pregnancy outcomes in twin\u2010 and singleton\u2010born women: An inter\u2010generational cohort study"],"prefix":"10.1111","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9022-9957","authenticated-orcid":false,"given":"Prativa","family":"Basnet","sequence":"first","affiliation":[{"name":"Department of Global Public Health and Primary Care University of Bergen  Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2983-1233","authenticated-orcid":false,"given":"Rolv","family":"Skj\u00e6rven","sequence":"additional","affiliation":[{"name":"Department of Global Public Health and Primary Care University of Bergen  Bergen Norway"},{"name":"Centre for Fertility and Health Norwegian Institute of Public Health  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5866-848X","authenticated-orcid":false,"given":"Quaker E.","family":"Harmon","sequence":"additional","affiliation":[{"name":"Epidemiology Branch National Institute of Environmental Health Sciences  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3726-5198","authenticated-orcid":false,"given":"Linn Marie","family":"S\u00f8rbye","sequence":"additional","affiliation":[{"name":"Norwegian Research Centre for Women's Health Oslo University Hospital, Rikshospitalet  Oslo Norway"},{"name":"Faculty of Health and Social Sciences Western Norway University of Applied Sciences  Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8256-0778","authenticated-orcid":false,"given":"Nils\u2010Halvdan","family":"Morken","sequence":"additional","affiliation":[{"name":"Department of Clinical Science University of Bergen  Bergen Norway"},{"name":"Department of Obstetrics and Gynaecology Haukeland University Hospital  Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2302-1723","authenticated-orcid":false,"given":"Aditi","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Global Public Health and Primary Care University of Bergen  Bergen 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