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Stillbirth has been relatively hidden during the COVID\u201019 pandemic, but a clear link between SARS\u2010CoV\u20102 and poor fetal outcome emerged in the Alpha and Delta waves. A small minority of women\/birthing people who contracted COVID\u201019 developed SARS\u2010CoV\u20102 placentitis. In many reported cases this was linked to intrauterine fetal death, although there are cases of delivery just before imminent fetal demise and we shall discuss how some cases are sub\u2010clinical. What is surprising, is that SARS\u2010CoV\u20102 placentitis is often not associated with severe maternal COVID\u201019 infection and this makes it difficult to predict. The worst outcomes seem to be with diffuse placental disease which occurs within 21\u2009days of COVID\u201019 diagnosis. Poor outcomes are often pre\u2010dated by reduced fetal movements but are not associated with ultrasound changes. In some cases, there has also been maternal thrombocytopenia, or coagulation abnormalities, which may provide a clue as to which pregnancies are at risk of fetal demise if a further variant of concern is to emerge. In future, multidisciplinary collaboration and cross\u2010boundary working must be prioritised, to identify quickly such a phenomenon and provide clinicians with clear guidance for reducing fetal death and associated poor outcomes. While we wait to see if COVID\u201019 brings a future variant of concern, we must focus on appropriate future management of women who have had SARS\u2010CoV\u20102 placentitis. As a placental condition with an infectious aetiology, SARS\u2010CoV\u2010placentitis is unlikely to recur in a subsequent pregnancy and thus a measured approach to subsequent pregnancy management is needed.<\/jats:p>","DOI":"10.1111\/1471-0528.17698","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T17:31:32Z","timestamp":1700587892000},"page":"385-400","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["SARS\u2010CoV\u20102\u2014Placental effects and association with stillbirth"],"prefix":"10.1111","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0352-2106","authenticated-orcid":false,"given":"Abi","family":"Merriel","sequence":"first","affiliation":[{"name":"Centre for Women's Health Research, Department of Women's and Children's Health University of Liverpool  Liverpool UK"},{"name":"Liverpool Women's Hospital  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"Department of Pathology Cork University Hospital  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keelin","family":"O\u2019Donoghue","sequence":"additional","affiliation":[{"name":"Pregnancy Loss Research Group, Department of Obstetrics and Gynaecology University College Cork  Cork Ireland"},{"name":"Cork University Maternity Hospital  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,20]]},"reference":[{"key":"e_1_2_19_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)30183\u20105"},{"key":"e_1_2_19_3_1","unstructured":"World Health Organization.WHO Health Emergency Dashboard (Coronavirus (Covid\u201019) Dashboard). 2022 [cited 2022 Dec 6]. 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