{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:02:49Z","timestamp":1790690569379,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"S8","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to compare the prevalence and neonatal mortality associated with large for gestational age (LGA) and macrosomia among 115.6\u2009million live births in 15 countries, between 2000 and 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Population\u2010based, multi\u2010country study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>National healthcare systems.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>Liveborn infants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used individual\u2010level data identified for the Vulnerable Newborn Measurement Collaboration. We calculated the prevalence and relative risk (RR) of neonatal mortality among live births born at term\u2009+\u2009LGA (&gt;90th centile, and also &gt;95th and &gt;97th centiles when the data were available) versus term\u2009+\u2009appropriate for gestational age (AGA, 10th\u201390th centiles) and macrosomic (\u22654000, \u22654500 and \u22655000\u2009g, regardless of gestational age) versus 2500\u20133999\u2009g. INTERGROWTH 21st served as the reference population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measures<\/jats:title>\n                    <jats:p>Prevalence and neonatal mortality risks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Large for gestational age was common (median prevalence 18.2%; interquartile range, IQR, 13.5%\u201322.0%), and overall was associated with a lower neonatal mortality risk compared with AGA (RR\u20090.83, 95%\u2009CI 0.77\u20130.89). Around one in ten babies were \u22654000\u2009g (median prevalence 9.6% (IQR 6.4%\u201313.3%), with 1.2% (IQR 0.7%\u20132.0%) \u22654500\u2009g and with 0.2% (IQR 0.1%\u20130.2%) \u22655000\u2009g). Overall, macrosomia of \u22654000\u2009g was not associated with increased neonatal mortality risk (RR\u20090.80, 95%\u2009CI 0.69\u20130.94); however, a higher risk was observed for birthweights of \u22654500\u2009g (RR\u20091.52, 95%\u2009CI 1.10\u20132.11) and \u22655000\u2009g (RR\u20094.54, 95%\u2009CI 2.58\u20137.99), compared with birthweights of 2500\u20133999\u2009g, with the highest risk observed in the first 7\u2009days of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this population, birthweight of \u22654500\u2009g was the most useful marker for early mortality risk in big babies and could be used to guide clinical management decisions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1471-0528.17706","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T22:55:15Z","timestamp":1701125715000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Neonatal mortality risk of large\u2010for\u2010gestational\u2010age and macrosomic live births in 15 countries, including 115.6\u2009million nationwide linked records, 2000\u20132020"],"prefix":"10.1111","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0909-7737","authenticated-orcid":false,"given":"Lorena","family":"Su\u00e1rez\u2010Idueta","sequence":"first","affiliation":[{"name":"Mexican Society of Public Health  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3116-2593","authenticated-orcid":false,"given":"Eric O.","family":"Ohuma","sequence":"additional","affiliation":[{"name":"Maternal, Adolescent, Reproductive &amp; Child Health (MARCH) Centre, London School of Hygiene &amp; Tropical Medicine  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Jung","family":"Chang","sequence":"additional","affiliation":[{"name":"Maternal, Adolescent, Reproductive &amp; Child Health (MARCH) Centre, London School of Hygiene &amp; Tropical Medicine  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9176-3278","authenticated-orcid":false,"given":"Elizabeth A.","family":"Hazel","sequence":"additional","affiliation":[{"name":"Department of International Health Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6299-2215","authenticated-orcid":false,"given":"Judith","family":"Yargawa","sequence":"additional","affiliation":[{"name":"Maternal, Adolescent, Reproductive &amp; Child Health (MARCH) Centre, London School of Hygiene &amp; Tropical Medicine  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4541-2856","authenticated-orcid":false,"given":"Yemisrach B.","family":"Okwaraji","sequence":"additional","affiliation":[{"name":"Maternal, Adolescent, Reproductive &amp; Child Health (MARCH) Centre, London School of Hygiene &amp; Tropical Medicine  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4457-0762","authenticated-orcid":false,"given":"Ellen","family":"Bradley","sequence":"additional","affiliation":[{"name":"Maternal, Adolescent, Reproductive &amp; Child Health (MARCH) Centre, London School of Hygiene &amp; Tropical Medicine  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2328-1066","authenticated-orcid":false,"given":"Adrienne","family":"Gordon","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health University of Sydney  Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5536-9468","authenticated-orcid":false,"given":"Jessica","family":"Sexton","sequence":"additional","affiliation":[{"name":"National Health and Medical Research Council (NHMRC) Centre of Research Excellence in Stillbirth, Mater Research Institute, The University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9699-8201","authenticated-orcid":false,"given":"Harriet L. 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