{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T13:02:07Z","timestamp":1776603727934,"version":"3.51.2"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T00:00:00Z","timestamp":1701648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Findings related to the association between persistent organic pollutants (POPs) and gestational diabetes mellitus (GDM) are inconclusive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To estimate the strength of the association between POP exposure and GDM in a systematic review with meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Search strategy<\/jats:title><jats:p>MEDLINE, Scopus and Web of Science were searched until July 2023.<\/jats:p><\/jats:sec><jats:sec><jats:title>Selection criteria<\/jats:title><jats:p>Cohort and case\u2013control studies analysing the association between POPs and GDM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data collection and analysis<\/jats:title><jats:p>We assessed the risk of bias using the Quality in Prognosis Studies scale (QUIPS). Standardised mean differences were pooled using random\u2010effect models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main results<\/jats:title><jats:p>Sixteen articles including 12\u2009216 participants were selected. The risk of bias was high in four articles (25%), moderate in 11 (68.75%) and low in one (6.25%). Small mean difference between GDM cases and controls was observed for PFHpA (0.26, 95% confidence interval [CI] 0.1\u20130.35, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.0%), PCB180 (0.37, 95% CI 0.19\u20130.56; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200925.3%), BDE47 (0.23, 95% CI 0.0\u20130.45, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090%), BDE99 (0.36, 95% CI 0.14\u20130.59; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090%), BDE100 (0.42, 95% CI 0.19\u20130.64; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090%) and HCB (0.22, 95% CI 0.01\u20130.42, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200939.6%). No considerable difference was observed for the rest of POPs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Small mean differences between GDM cases and controls were observed for some POPs. However, evidence shows mostly moderate quality and results were heterogeneous. Improved research methodology is needed to assess POPs and GDM risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.17725","type":"journal-article","created":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T08:09:00Z","timestamp":1701677340000},"page":"579-588","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Persistent organic pollutant exposure as a risk factor of gestational diabetes mellitus: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3797-045X","authenticated-orcid":false,"given":"Malak","family":"Kouiti","sequence":"first","affiliation":[{"name":"Departamento de Medicina Preventiva y Salud P\u00fablica Universidad de Granada  Granada Spain"},{"name":"Laboratory of Health Sciences and Technologies, Higher Institute of Health Sciences Hassan First University of Settat  Settat Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda \u00c1ngeles","family":"Castillo\u2010Hermoso","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Preventiva y Salud P\u00fablica Universidad de Granada  Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibtissam","family":"Youlyouz\u2010Marfak","sequence":"additional","affiliation":[{"name":"Laboratory of Health Sciences and Technologies, Higher Institute of Health Sciences Hassan First University of Settat  Settat Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5084-7312","authenticated-orcid":false,"given":"Khalid Saeed","family":"Khan","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Preventiva y Salud P\u00fablica Universidad de Granada  Granada Spain"},{"name":"Consorcio Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shakila","family":"Thangaratinam","sequence":"additional","affiliation":[{"name":"Institute for Metabolism and Systems Research University of Birmingham  Birmingham UK"},{"name":"Birmingham Women's and Children's National Health Service Foundation Trust  Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roc\u00edo","family":"Olmedo\u2010Requena","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Preventiva y Salud P\u00fablica Universidad de Granada  Granada Spain"},{"name":"Consorcio Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP)  Madrid Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA  Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Zamora","sequence":"additional","affiliation":[{"name":"Consorcio Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP)  Madrid Spain"},{"name":"Institute for Metabolism and Systems Research University of Birmingham  Birmingham UK"},{"name":"Birmingham Women's and Children's National Health Service Foundation Trust  Birmingham UK"},{"name":"Clinical Biostatistics Unit Hospital Ramon y Cajal (IRYCIS)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Juan","family":"Jim\u00e9nez\u2010Mol\u00e9on","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Preventiva y Salud P\u00fablica Universidad de Granada  Granada Spain"},{"name":"Consorcio Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP)  Madrid Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA  Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,4]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"Stockholm Convention.What are POPs?2001. 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