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Treated clinical hyperandrogenism was defined as filled prescriptions of anti\u2010androgenic drugs during 2005\u20132017 (<jats:italic>n<\/jats:italic>\u2009=\u20092301 among PCOS women).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The risk of pre\u2010eclampsia was estimated with conditional logistic regression, expressed as adjusted odds ratio (OR) with 95% confidence interval (CI). Adjustments were performed individually for confounders and predictors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Overall pre\u2010eclampsia. Early\/late (delivery &lt;34\/\u226534\u2009weeks) pre\u2010eclampsia. Pre\u2010eclampsia with or without a small\u2010for\u2010gestational\u2010age (SGA) infant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with controls, women with PCOS had a 29% increased risk of pre\u2010eclampsia (predictor adjusted OR 1.29, 95% CI 1.20\u20131.39), with similar risk estimates for PCOS women with and without treated clinical hyperandrogenism. The association between PCOS and early pre\u2010eclampsia seemed stronger than its association with late pre\u2010eclampsia (predictor adjusted OR 1.64 (95% CI 1.33\u20132.02) and 1.26 (95% CI 1.17\u20131.37). Additionally, the association seemed slightly stronger between PCOS and pre\u2010eclampsia in women with an SGA infant than without.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Women with PCOS face an increased risk for pre\u2010eclampsia, especially early pre\u2010eclampsia and pre\u2010eclampsia with an SGA infant. We were unable to determine on the basis of available data, whether hyperandrogenism is associated with pre\u2010eclampsia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.17734","type":"journal-article","created":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T19:38:38Z","timestamp":1702409918000},"page":"985-995","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Polycystic ovary syndrome and risk of pre\u2010eclampsia: A national register\u2010based cohort study"],"prefix":"10.1111","volume":"131","author":[{"given":"Ragnheidur","family":"Valdimarsdottir","sequence":"first","affiliation":[{"name":"Department of Women's and Children's Health Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eszter","family":"Vanky","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine Norwegian University of Science and Technology  Trondheim Norway"},{"name":"Department of Obstetrics and Gynaecology St. Olavs Hospital, Trondheim University Hospital  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2253-4682","authenticated-orcid":false,"given":"Evangelia","family":"Elenis","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Lindstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Junus","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Jonsson","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inger","family":"Sundstr\u00f6m\u00a0Poromaa","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna\u2010Karin","family":"Wikstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,11]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew218"},{"key":"e_1_2_12_3_1","unstructured":"International evidence\u2010based guideline for the assessment and management of polycystic ovary syndrome 2023. 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