{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:52:31Z","timestamp":1790502751924,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"S3","license":[{"start":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T00:00:00Z","timestamp":1712793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T00:00:00Z","timestamp":1712793600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100016195","name":"United Nations Development Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016195","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004423","name":"World Health Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004423","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine the prevalence, perinatal outcomes and factors associated with neonatal sepsis in referral\u2010level facilities across Nigeria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Secondary analysis of data from the Maternal and Perinatal Database for Quality, Equity and Dignity Programme in 54 referral\u2010level hospitals across Nigeria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Records covering the period from 1 September 2019 to 31 August 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>Mothers admitted for birth during the study period, and their live newborns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Analysis of prevalence and sociodemographic and clinical factors associated with neonatal sepsis and perinatal outcomes. Multilevel logistic regression modelling identified factors associated with neonatal sepsis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measures<\/jats:title>\n                    <jats:p>Neonatal sepsis and perinatal outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The prevalence of neonatal sepsis was 16.3 (95%\u2009CI 15.3\u201317.2) per 1000 live births (1113\/68\u2009459) with a 10.3% (115\/1113) case fatality rate. Limited education, unemployment or employment in sales\/trading\/manual jobs, nulliparity\/grand multiparity, chronic medical disorder, lack of antenatal care (ANC) or ANC outside the birthing hospital and referral for birth increased the odds of neonatal sepsis. Birthweight of &lt;2500\u2009g, non\u2010spontaneous vaginal birth, preterm birth, prolonged rupture of membranes, APGAR score of &lt;7 at 5\u2009min, birth asphyxia, birth trauma or jaundice were associated with neonatal sepsis. Neonates with sepsis were more frequently admitted to a neonatal intensive care unit (1037\/1110, 93.4% vs 8237\/67\u2009346, 12.2%) and experienced a higher rate of death (115\/1113, 10.3% vs 933\/67\u2009343, 1.4%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Neonatal sepsis remains a critical challenge in neonatal care, underscored by its high prevalence and mortality rate. The identification of maternal and neonatal risk factors underscores the importance of improved access to education and employment for women and targeted interventions in antenatal and intrapartum care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1471-0528.17824","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T05:41:08Z","timestamp":1712814068000},"page":"101-112","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Prevalence, perinatal outcomes and factors associated with neonatal sepsis in Nigeria"],"prefix":"10.1111","volume":"131","author":[{"given":"Chinyere Ukamaka","family":"Onubogu","sequence":"first","affiliation":[{"name":"Department of Paediatrics Nnamdi Azikiwe University Teaching Hospital  Nnewi Nigeria"},{"name":"Department of Paediatrics Nnamdi Azikiwe University, Faculty of Medicine  Nnewi Campus Anambra State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uchenna","family":"Ekwochi","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Enugu State University Teaching Hospital  Parklane Enugu State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ijeoma","family":"Obumneme\u2010Anyim","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University of Nigeria Teaching Hospital  Ituku Ozalla Enugu State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda Nneka","family":"Nwokeji\u2010Onwe","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Alex Ekwueme Federal University Teaching Hospital  Abakaliki Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George Uchenna","family":"Eleje","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Nnamdi Azikiwe University, Faculty of Medicine  Nnewi Campus Anambra State Nigeria"},{"name":"Department of Obstetrics and Gynaecology Nnamdi Azikiwe University Teaching Hospital  Nnewi Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nnabuike Okechukwu","family":"Ojiegbe","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Federal Medical Center  Umuahia Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ifeanyichukwu Uzoma","family":"Ezebialu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Chukwuemeka Odumegwu Ojukwu University Teaching Hospital  Awka Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eziamaka Pauline","family":"Ezenkwele","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of Nigeria Teaching Hospital  Ituku Ozalla Enugu State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily Akuabia","family":"Nzeribe","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Federal Medical Centre  Owerri Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uchenna Anthony","family":"Umeh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of Nigeria Teaching Hospital  Ituku Ozalla Enugu State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Innocent Anayochukwu","family":"Ugwu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; 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